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Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium.
BACKGROUND Ocular trauma or disease may lead to severe corneal opacification and, consequently, severe loss of vision as a result of complete loss of corneal epithelial stem cells. Transplantation ofExpand
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A new isolation method of human limbal progenitor cells by maintaining close association with their niche cells.
In human corneal epithelium, self-renewal and fate decision of stem cells are highly regulated in a niche microenvironment called palisades of Vogt in the limbus. Herein, we discovered that digestionExpand
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A novel method of isolation, preservation, and expansion of human corneal endothelial cells.
PURPOSE To explore new strategies for effective isolation, preservation, and expansion of human corneal endothelial cells (HCECs). METHODS Human corneal Descemet's membrane and corneal endothelialExpand
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Niche regulation of corneal epithelial stem cells at the limbus
Among all adult somatic stem cells, those of the corneal epithelium are unique in their exclusive location in a defined limbal structure termed Palisades of Vogt. As a result, surgical engraftment ofExpand
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Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface
Background. Limbal stem-cell deficiency by ocular trauma or diseases causes corneal opacification and visual loss. Recent attempts have been made to fabricate corneal epithelial graft constructs, butExpand
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Functional human corneal endothelial cell sheets harvested from temperature‐responsive culture surfaces
This study reports a new method for fabricating bioengineered human corneal endothelial cell sheets suitable for ocular surgery and repair. We have initially cultured human corneal endothelial cellsExpand
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Characterization and comparison of intercellular adherent junctions expressed by human corneal endothelial cells in vivo and in vitro.
PURPOSE Human corneal endothelial cell (HCEC) proliferation is controlled by HCEC junctions, but the mechanism of proliferation remains unknown. The authors sought to characterize adherent junctionExpand
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The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membrane.
PURPOSE The clinical success of treating corneas with total limbal stem cell deficiency using limbal biopsy explants cultured on intact amniotic membrane (iAM) relies on ex vivo expansion of limbalExpand
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The use of amniotic membrane in reducing adhesions after strabismus surgery.
Postoperative adhesions after strabismus surgery may influence surgical outcome. Different techniques have been used with varying success to reduce these adhesions. We describe a novel surgicalExpand
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Suppression of activation and induction of apoptosis in RAW264.7 cells by amniotic membrane extract.
  • H. He, W. Li, +5 authors S. Tseng
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 1 October 2008
PURPOSE Macrophages play a pivotal role in initiating, maintaining, and resolving host inflammatory/immune responses but may cause recalcitrant inflammation and tissue damage if not controlled.Expand
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