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Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test
This new system quantitatively simulated human absorption and would be beneficial for the prediction of human Fa values for BCS class II drugs.
Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation
The model quantitatively predicted results observed in vivo, including but not exclusively, dissolution-rate-limited and solubility-limited absorption, which will aid in the success of BCS class II drug development.
Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds
- Koji Shiraki, Noriyuki Takata, R. Takano, Y. Hayashi, K. Terada
- Materials SciencePharmaceutical Research
- 24 July 2008
Cocrystallizations of exemestane and megestrol acetate from cocrystallization using various particle sizes improved initial dissolution rates compared to the respective original crystals.
Entrapment of Proteins in Poly(L-Lactide) Microspheres Using Reversed Micelle Solvent Evaporation
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
This work successfully substituted the right-hand imidazole ring with a branched alkyl chain at the 5-position in 1 with a simpler 2-pyridyl structure by converting the left-hand ring from a phenyl to a benzophenone structure without decreasing the potency.
A diterpene quinone from the bark of Cryptomeria japonica.
Cocrystal Screening of Stanolone and Mestanolone Using Slurry Crystallization
A slurry crystallization technique was used in cocrystal screening of two nonionizable pharmaceutical host compounds, stanolone and mestanolone, with 11 pharmaceutically acceptable guest acids.…
Analysis of cyclopiazonic acid in corn and rice by a newly developed method
Click strategy using disodium salts of amino acids improves the water solubility of plinabulin and KPU-300.
Temperature control of biotin binding and release with A streptavidin-poly(N-isopropylacrylamide) site-specific conjugate.
- Z. Ding, C. Long, Y. Hayashi, E. Bulmuş, A. Hoffman, P. Stayton
- Chemistry, BiologyBioconjugate chemistry
- 22 April 1999
A streptavidin-PNIPAAm conjugate is constructed which is able to bind biotin at room temperature or lower and release boundBiotin at 37 degrees C and can repeatedly bind and release biotin as temperature is cycled through the LCST.