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Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test
TLDR
This new system quantitatively simulated human absorption and would be beneficial for the prediction of human Fa values for BCS class II drugs.
Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation
TLDR
The model quantitatively predicted results observed in vivo, including but not exclusively, dissolution-rate-limited and solubility-limited absorption, which will aid in the success of BCS class II drug development.
Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds
TLDR
Cocrystallizations of exemestane and megestrol acetate from cocrystallization using various particle sizes improved initial dissolution rates compared to the respective original crystals.
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
TLDR
This work successfully substituted the right-hand imidazole ring with a branched alkyl chain at the 5-position in 1 with a simpler 2-pyridyl structure by converting the left-hand ring from a phenyl to a benzophenone structure without decreasing the potency.
Cocrystal Screening of Stanolone and Mestanolone Using Slurry Crystallization
A slurry crystallization technique was used in cocrystal screening of two nonionizable pharmaceutical host compounds, stanolone and mestanolone, with 11 pharmaceutically acceptable guest acids.
Temperature control of biotin binding and release with A streptavidin-poly(N-isopropylacrylamide) site-specific conjugate.
TLDR
A streptavidin-PNIPAAm conjugate is constructed which is able to bind biotin at room temperature or lower and release boundBiotin at 37 degrees C and can repeatedly bind and release biotin as temperature is cycled through the LCST.
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