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Low tumor incidence in rats with long-term feeding of fusarenon-X, a cytotoxic trichothecene produced by Fusarium nivale.
In order to examine tumorigenic effects of fusarenon-X, a trichothecene compound produced by Fusarium nivale, feeding experiments on 151 male Donryu rats were carried out. Daily dose of 105…
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Toxicological approaches to the metabolites of Fusaria. XIII. Hematological changes in mice by a single and repeated administrations of trichothecenes.
A single or repeated administration of trichothecene mycotoxins to mice induced leukocytosis and leukopenia. Acute and sub-acute toxicosis of trichothecenes was characterized by hematological and…
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Cytotoxicity and carcinogenicity of pterosins and pterosides, 1-indanone derivatives from bracken (Pteridium aquilinum)
Über 30 Chemikalien aus getrockneten jungen Blättern und Wurzelstöcken des japanischen FarnkrautesPteridium aquilinum wurden isoliert und als Sesquiterpen-Derivate mit 1-Indanonkern, Pterosine und…
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Hepato- and cardiotoxicity of xanthoascin, a new metabolite of A. candidus Link, to mice. I. Blood chemistry and histological changes in mice.
TLDR
The unique nature of lesions in the liver and heart may necessitate further investigations in the field of mycotoxicology in relation to human diseases such as nutritional hepatitis and primary myocardial degeneration.
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EFFECTS OF DOSAGE AND SEX ON THE LIVER INJURY AND INCIDENCE OF HEPATOCELLULAR TUMORS INDUCED BY 3-BENZYLSYDNONE-4-ACETAMIDE IN RATS
TLDR
Initially BSA caused centrilobular necrosis of the liver, with elevated serum GPT activity, then appeared proliferating liver cell clusters from which adenomatous and neoplastic changes developed.
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