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Protrudin Regulates Endoplasmic Reticulum Morphology and Function Associated with the Pathogenesis of Hereditary Spastic Paraplegia*
Background: Certain hereditary spastic paraplegia (HSP)-related proteins possess hairpin domains and regulate the morphology of the endoplasmic reticulum (ER) network. Results: Protrudin possesses aExpand
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Sterol analysis of DMI-resistant and -sensitive strains of Venturia inaequalis
The sterol composition of Venturia inaequalis strains sensitive and resistant to sterol demethylation-inhibiting fungicides (DMI) were analysed. Without DMI treatment, both strains containedExpand
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Ring-A cleavage of 3-oxo-olean-12-en-28-oic acid by the fungus Chaetomium longirostre
Abstract 3-Oxo-olean-12-en-28-oic acid was transformed by the filamentous fungus Chaetomium longirostre into 3,4- seco -olean-12-en-4-ol-3,28-dioic acid and the 21β-hydroxylated compound. A cell-freeExpand
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Development of ambient sampling chemi/chemical ion source with dielectric barrier discharge.
The development of a new configuration of chemical ionization (CI)-based ion source is presented. The ambient air containing the gaseous sample is sniffed into an enclosed ionization chamber which isExpand
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Identification and characterization of a neuron‐specific isoform of protrudin
Protrudin is a membrane protein that regulates polarized vesicular transport. Now, we have identified a novel isoform of protrudin (protrudin‐L) that contains an additional seven amino acids betweenExpand
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TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation
Mammalian/mechanistic target of rapamycin complex 1 (mTORC1) responds to growth factors and nutrient availability. Amino acids induce the recruitment of mTORC1 to the lysosomal membrane and itsExpand
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Application of probe electrospray to direct ambient analysis of biological samples.
Recently, we have developed probe electrospray ionization (PESI) that uses a solid needle. In this system, the probe needle moves up and down along the vertical axis by a motor-driven system. At theExpand
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Quantitative method for etoposide in biological gans by HPLC.
抗しゅよう剤であるエトポシドの簡便な臓器内濃度定量法を開発した.本法は,簡易型プレパックドカラムであるClin ElutTMとBond ElutTMExpand
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Rapid detection of drugs in biofluids using atmospheric pressure chemi/chemical ionization mass spectrometry.
We have demonstrated that, with simple pH adjustment, volatile drugs such as methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), ketamine, and valproic acid could be analyzedExpand
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