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Allosteric regulation of a ribozyme activity through ligand-induced conformational change.
An allosteric ribozyme has been designed using the hammerhead ribozyme as the active site and aflavin-specific RNA aptamer as a regulatory site. We constructed six variants with a series of baseExpand
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Heavy photon states in photonic chains of resonantly coupled cavities with supermonodispersive microspheres.
We propose and demonstrate a "bottom-up" approach to constructing photonic structures for photon manipulation. Supermonodispersive polymer microspheres are used as building blocks and a sizeExpand
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Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms.
BACKGROUND It is well known that vagal stimulation increases the vulnerability to atrial fibrillation via muscarinic receptor-mediated shortening of refractory period. Recently it has been reportedExpand
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Serum substances that interfere with thyroid hormone assays in patients with chronic renal failure
Serum thyroid hormone concen_trations in patients with chronic renal failure are usually low, despite normal serum TSH levels. We investigated the effect on thyroid hormone assays of serum dialysableExpand
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Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents.
AH-1058 is a newly synthesized antiarrhythmic agent. We investigated the antiarrhythmic and electrophysiological effects of AH-1058 in experimental arrhythmia models and isolated cardiomyocytes. InExpand
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Functional expression of thiocyanate hydrolase is promoted by its activator protein, P15K
Thiocyanate hydrolase (SCNase) is a cobalt‐containing enzyme with a post‐translationally modified cysteine ligand, γCys131‐SO2H. When the SCNase α, β and γ subunits were expressed in EscherichiaExpand
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  • Open Access
Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats
Background There is increasing evidence to support the importance of blocking aldosterone to prevent target-organ damage in hypertension. We recently demonstrated an aldosterone breakthroughExpand
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Effects of AT1 Receptor Antagonist and Spironolactone on Cardiac Expression of ET-1 mRNA in SHR-SP/Izm
Angiotensin II stimulates and angiotensin-converting enzyme inhibitor decreases endothelin-1 expression. Effects of the angiotensin-type 1 antagonist (angiotensin receptor blocker) on tissueExpand
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Bradykinin B2‐receptor‐mediated modulation of membrane currents in guinea‐pig cardiomyocytes
1 In order to define the electrophysiological mechanism(s) responsible for bradykinin (BK)‐induced positive inotropic and chronotropic responses in isolated guinea‐pig atria, effects of BK on theExpand
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