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Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment
Age-associated memory impairment (AAMI) occurs in many mammalian species, including humans. In contrast to Alzheimer's disease (AD), in which circuit disruption occurs through neuron death, AAMI isExpand
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Synaptic Estrogen Receptor-α Levels in Prefrontal Cortex in Female Rhesus Monkeys and Their Correlation with Cognitive Performance
In rat hippocampus, estrogen receptor-α (ER-α) can initiate nongenomic signaling mechanisms that modulate synaptic plasticity in response to either circulating or locally synthesized estradiol (E).Expand
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Astrocytic tight junctions control inflammatory CNS lesion pathogenesis
Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across theExpand
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Expression patterns of Hox genes in larvae of the sea lily Metacrinus rotundus
We cloned eight Hox genes (MrHox1, MrHox2, MrHox4, MrHox5, MrHox7, MrHox8, MrHox9/10, and MrHox11/13c) from the sea lily Metacrinus rotundus, a member of the most basal group of the extantExpand
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Cytomegalovirus as an etiologic factor in corneal endotheliitis.
PURPOSE To investigate clinical manifestations and response to antiviral therapy of 8 patients with cytomegalovirus (CMV)-induced corneal endotheliitis who were diagnosed and treated at 2 universityExpand
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Neuronal and morphological bases of cognitive decline in aged rhesus monkeys
Rhesus monkeys provide a valuable model for studying the basis of cognitive aging because they are vulnerable to age-related decline in executive function and memory in a manner similar to humans.Expand
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Prodynorphin storage and processing in axon terminals and dendrites
The classical view postulates that neuropeptide precursors in neurons are processed into mature neuropeptides in the somatic trans‐Golgi network (TGN) and in secretory vesicles during axonalExpand
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Larval stages of a living sea lily (stalked crinoid echinoderm)
The embryos and larvae of stalked crinoids, which are considered the most basal group of extant echinoderms, have not previously been described. In contrast, much is known about the development ofExpand
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Dopamine D1 receptors have subcellular distributions conducive to interactions with prodynorphin in the rat nucleus accumbens shell
Activation of dopamine (DA) D1 receptors (D1Rs) in the nucleus accumbens (Acb) markedly affects the levels of prodynorphin, the precursor of aversion‐associated dynorphin peptides. The location ofExpand
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Regrowth of the stalk of the sea lily, Metacrinus rotundus (Echinodermata: Crinoidea).
Sea lilies are critical to understanding the evolution of the echinoderm body plan, because they are the only extant group whose adults possess a stalk, a prevalent feature in the radiation of aExpand
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