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HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.
Three new oligostilbenes, malibatols A (1) and B (2) and dibalanocarpol (3), together with one known oligostilbene balanocarpol (4), were isolated from the organic extract of the leaves of HopeaExpand
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Anti-HIV michellamines from Ancistrocladus korupensis.
Here we report details of the isolation and determination of the absolute configurations and comparative anti-HIV activities of novel, atropisomeric naphthylisoquinoline alkaloid dimers,Expand
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Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.
Four novel anti-HIV macrocyclic peptides containing 28-31 amino acid residues, named cycloviolins A-D, have been isolated from the hitherto unstudied tropical plant Leonia cymosa. Their primaryExpand
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Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms.
Studies of the mechanism of action of michellamine B, a novel anti-human immunodeficiency virus (HIV) alkaloid from the tropical plant Ancistrocladus korupensis, have revealed that the compound actsExpand
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Phytotoxins from Alternaria cassiae
Abstract The isolation, structure determination, and phytotoxicity of stemphyperylenol, stemphyltoxin II, alterperylenol, and altertoxin I from Alternaria cassiae are reported.
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Phytoactive Eremophilanes Produced by the Weed Pathogen Drechslera gigantea.
Phytoactive substances were present in a culture broth of Drechslera gigantea, a pathogenic fungus of several grasses. Twelve eremophilane sesquiterpenes (1, 2, 3, 4, 6, 7, 10, 11, 12, 13, 14, andExpand
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National Cooperative Drug Discovery Groups (NCDDGs): A Successful Model for Public Private Partnerships in Cancer Drug Discovery
The United States National Cancer Institute (NCI) has been investigating Nature as a source of novel agents for the treatment of cancer for over 45 years, and has contributed to the development ofExpand
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Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures wereExpand
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Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis.
A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana AncistrocladusExpand
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A new discorhabdin from two sponge genera.
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