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Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.
Four novel anti-HIV macrocyclic peptides containing 28-31 amino acid residues, named cycloviolins A-D, have been isolated from the hitherto unstudied tropical plant Leonia cymosa and showed high degrees of sequence homology to the known cyclopsychotride A and circulins A and B from the Rubiaceae family but much less homologyTo the varv peptides from Viola, a member of the same family (Violaceae).
Phytotoxins from Alternaria cassiae
Abstract The isolation, structure determination, and phytotoxicity of stemphyperylenol, stemphyltoxin II, alterperylenol, and altertoxin I from Alternaria cassiae are reported.
Anti-HIV michellamines from Ancistrocladus korupensis.
Here we report details of the isolation and determination of the absolute configurations and comparative anti-HIV activities of novel, atropisomeric naphthylisoquinoline alkaloid dimers,
HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.
Three new oligostilbenes were isolated from the organic extract of the leaves of Hopea malibato and exhibited very modest HIV-inhibitory activity, while compounds 1 and 2 were cytotoxic to the host cells (CEM SS) in the antiviral assay.
National Cooperative Drug Discovery Groups (NCDDGs): A Successful Model for Public Private Partnerships in Cancer Drug Discovery
The National Cooperative Drug Discovery Group program was started in 1983 as mechanism to promote multidisciplinary, multi-institutional approaches to drug discovery, and has led to the development of a number of successful clinical agents.
Phytoactive Eremophilanes Produced by the Weed Pathogen Drechslera gigantea.
Most of these sesquiterpenoids were phytotoxic; however, compounds 1 and 3 caused chlorophyll retention, an activity previously associated with phytohormones.
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were
Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms
Studies of the mechanism of action of michellamine B, a novel anti-human immunodeficiency virus (HIV) alkaloid from the tropical plant Ancistrocladus korupensis, have revealed that the compound acts
Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis.
Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.