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Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.
TLDR
Four novel anti-HIV macrocyclic peptides containing 28-31 amino acid residues, named cycloviolins A-D, have been isolated from the hitherto unstudied tropical plant Leonia cymosa and showed high degrees of sequence homology to the known cyclopsychotride A and circulins A and B from the Rubiaceae family but much less homologyTo the varv peptides from Viola, a member of the same family (Violaceae).
Phytotoxins from Alternaria cassiae
Abstract The isolation, structure determination, and phytotoxicity of stemphyperylenol, stemphyltoxin II, alterperylenol, and altertoxin I from Alternaria cassiae are reported.
Anti-HIV michellamines from Ancistrocladus korupensis.
Here we report details of the isolation and determination of the absolute configurations and comparative anti-HIV activities of novel, atropisomeric naphthylisoquinoline alkaloid dimers,
HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.
TLDR
Three new oligostilbenes were isolated from the organic extract of the leaves of Hopea malibato and exhibited very modest HIV-inhibitory activity, while compounds 1 and 2 were cytotoxic to the host cells (CEM SS) in the antiviral assay.
National Cooperative Drug Discovery Groups (NCDDGs): A Successful Model for Public Private Partnerships in Cancer Drug Discovery
TLDR
The National Cooperative Drug Discovery Group program was started in 1983 as mechanism to promote multidisciplinary, multi-institutional approaches to drug discovery, and has led to the development of a number of successful clinical agents.
Phytoactive Eremophilanes Produced by the Weed Pathogen Drechslera gigantea.
TLDR
Most of these sesquiterpenoids were phytotoxic; however, compounds 1 and 3 caused chlorophyll retention, an activity previously associated with phytohormones.
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were
Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms
Studies of the mechanism of action of michellamine B, a novel anti-human immunodeficiency virus (HIV) alkaloid from the tropical plant Ancistrocladus korupensis, have revealed that the compound acts
Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis.
TLDR
Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.
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