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Noble Gases Without Anesthetic Properties Protect Myocardium Against Infarction by Activating Prosurvival Signaling Kinases and Inhibiting Mitochondrial Permeability Transition In Vivo
BACKGROUND:The anesthetic noble gas, xenon, produces cardioprotection. We hypothesized that other noble gases without anesthetic properties [helium (He), neon (Ne), argon (Ar)] also produceExpand
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Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients
Background Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated inExpand
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Incidence and risk factors of acute kidney injury after thoracic aortic surgery for acute dissection.
BACKGROUND Previous studies have reported a high incidence of acute kidney injury (AKI) after thoracic aortic surgery in heterogeneous patient cohorts, including various aortic diseases and the useExpand
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Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production via Forward versus Reverse Electron Transport Flow: Implications for Preconditioning
Background: Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms of ROS generation remain unclear. InExpand
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Magnesium Sulfate Prevents Remifentanil-Induced Postoperative Hyperalgesia in Patients Undergoing Thyroidectomy
BACKGROUND: In a randomized, double-blind, prospective study, we investigated whether an intraoperative high versus low dose of remifentanil increased postoperative hyperalgesia and whether magnesiumExpand
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Xenon Preconditioning: The Role of Prosurvival Signaling, Mitochondrial Permeability Transition and Bioenergetics in Rats
BACKGROUND: Similar to volatile anesthetics, the anesthetic noble gas xenon protects the heart from ischemia/reperfusion injury, but the mechanisms responsible for this phenomenon are not fullyExpand
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Pregabalin reduces post‐operative pain after mastectomy: a double‐blind, randomized, placebo‐controlled study
Background: Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in post‐operative pain. The aim of this randomized, double‐blinded, placebo‐controlled trialExpand
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Inhibition of Glycogen Synthase Kinase or the Apoptotic Protein p53 Lowers the Threshold of Helium Cardioprotection In Vivo: The Role of Mitochondrial Permeability Transition
BACKGROUND:Prosurvival signaling kinases inhibit glycogen synthase kinase-3&bgr; (GSK-3&bgr;) activity and stimulate apoptotic protein p53 degradation. Helium produces cardioprotection by activatingExpand
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The Mechanism of Helium-Induced Preconditioning: A Direct Role for Nitric Oxide in Rabbits
BACKGROUND:Helium produces preconditioning against myocardial infarction by activating prosurvival signaling, but whether nitric oxide (NO) generated by endothelial NO synthase plays a role in thisExpand
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Reactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo.
OBJECTIVES Helium produces preconditioning by activating prosurvival kinases, but the roles of reactive oxygen species (ROS) or mitochondrial adenosine triphosphate-regulated potassium (K(ATP))Expand
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