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Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells
12 flavonoids were isolated from the roots of A. membranaceus and the effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated, showing significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production.
Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose.
  • C. Choi, Y. Choi, S. Ryu
  • Chemistry, Medicine
    Journal of agricultural and food chemistry
  • 24 August 2010
In the course of searching for new classes of α-glucosidase inhibitors originated from natural resources, 11 kinds of isoflavones, i.e., medicarpin (1), formononetin (2), mucronulatol (3),
Quantitative determination of salidroside and tyrosol from the underground part ofRhodiola rosea by high performance liquid chromatography
A reversed-phase high performance liquid chromatographic method was developed to determine salidroside and tyrosol simultaneously in theRhodiola rosea. The optimum condition was Nova-Pak C18 as
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.
Two new sesquiterpene esters are reported, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran and 1beta-acetoxyl -2beta, 6alpha, 9alpha-trifuroyoxydicelastrol, which showed moderate inhibition in both NF-kappaB activation and nitric oxide production.
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum.
  • M. Na, W. Oh, J. Ahn
  • Chemistry, Medicine
    Bioorganic & medicinal chemistry letters
  • 1 June 2006
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.
Methanol extract of Ficus leaf inhibits the production of nitric oxide and proinflammatory cytokines in LPS‐stimulated microglia via the MAPK pathway
MFL inhibited LPS‐induced production of NO and pro inflammatory cytokines in a dose‐dependent manner and attenuated the expression of mRNA and proteins of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines, suggesting the blockage of transcription levels, respectively.