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Zinc as a paracrine effector in pancreatic islet cell death.
Because of a huge amount of Zn2+ in secretory granules of pancreatic islet beta-cells, Zn2+ released in certain conditions might affect the function or survival of islet cells. We studied potentialExpand
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  • Open Access
Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models
Aims/hypothesisIL-6 is a proinflammatory cytokine associated with the pathogenesis of hepatic diseases. Metformin is an anti-diabetic drug used for the treatment of type 2 diabetes, and orphanExpand
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Expression of 14-3-3 ζ and interaction with protein kinase C in the rat retina in early diabetes
Aims/hypothesisThe present study aimed to investigate the expression levels of and the relationship between 14-3-3 ζ and protein kinase C (PKC) in the retina of early diabetes.MethodsChanges in theExpand
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Cyclosporin A and sanglifehrin A enhance chemotherapeutic effect of cisplatin in C6 glioma cells.
Glioma is the most common type of brain tumors in adults, and treatment of high-grade gliomas is still palliative. Studies to date have revealed only modest effect in attenuating growth of theseExpand
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  • Open Access
The effectiveness of postoperative neutrophils to lymphocytes ratio in predicting long-term recurrence after stomach cancer surgery
Purpose Immunosuppression is a characteristic of cancer recurrence after curative resection. The neutrophil-to-lymphocyte ratio (NL ratio) in peripheral blood is associated with immune function.Expand
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Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo
Diabetic nephropathy is characterized by an expansion of glomerular mesangium, caused by mesangial cell proliferation and excessive accumulation of extracellular matrix (ECM) proteins, whichExpand
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RhoA/Rho kinase blocks muscle differentiation via serine phosphorylation of insulin receptor substrate-1 and -2.
Although the RhoA/Rho kinase (RhoA/ROK) pathway has been extensively investigated, its roles and downstream signaling pathways are still not well understood in myogenic processes. Therefore, weExpand
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Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation.
Role of c-Src in muscle differentiation has been controversial. Here, we investigated if c-Src positively or negatively regulates muscle differentiation, using H9c2 and C2C12 cell lines. InhibitionExpand
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Functional Recovery of Diabetic Mouse Hearts by Glutaredoxin-1 Gene Therapy: Role of Akt-FoxO Signaling Network
Recent studies suggest that glutaredoxin-1 (Glrx-1) may serve as therapeutic target for diabetic hearts. As the level of reactive oxygen species (ROS) is increased in the pathologic hearts includingExpand
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Does single-port laparoscopic surgery reduce postoperative pain in women with benign gynecologic disease?
BACKGROUND Reduced postoperative pain, one of the potential benefits of single-port laparoscopic surgery (SP-LS), has clinically significant importance. The objectives of this study are to compareExpand
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