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Protein Kinase C&egr; Interacts With and Inhibits the Permeability Transition Pore in Cardiac Mitochondria
Abstract— Although functional coupling between protein kinase C&egr; (PKC&egr;) and mitochondria has been implicated in the genesis of cardioprotection, the signal transduction mechanisms that enable… Expand
The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a…
Seventy-four conscious rabbits undergoing a sequence of six 4-minute coronary occlusion/4-minute reperfusion cycles for 3 consecutive days (days 1, 2, and 3) were assigned to nine groups. In group I… Expand
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene.
- Y. Guo, W. Jones, +9 authors R. Bolli
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 28 September 1999
The goal of this study was to interrogate the role of inducible NO synthase (iNOS) in the late phase of ischemic preconditioning (PC) in vivo. A total of 321 mice were used. Wild-type mice… Expand
Cells Expressing Early Cardiac Markers Reside in the Bone Marrow and Are Mobilized Into the Peripheral Blood After Myocardial Infarction
The concept that bone marrow (BM)–derived cells participate in cardiac regeneration remains highly controversial and the identity of the specific cell type(s) involved remains unknown. In this study,… Expand
Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning.
More than 10 years after its discovery, the function of cyclooxygenase-2 (COX-2) in the cardiovascular system remains largely an enigma. Many scholars have assumed that the allegedly detrimental… Expand
Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism.
The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies… Expand
IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.
OBJECTIVE We sought to determine whether interleukin (IL)-6 modulates myocardial infarction or the late phase of preconditioning (PC). METHODS Wild-type and IL-6(-/-) mice underwent a 30-min… Expand
The nitric oxide hypothesis of late preconditioning
Abstract Ischemic preconditioning (PC) occurs in two phases: an early phase, which lasts 2–3 h, and a late phase, which begins 12–24 h later and lasts 3–4 days. The mechanism for the late phase of PC… Expand
The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis.
- X. Bai, J. Q. Liu, +5 authors Y. Liu
- Biology, Medicine
- The Journal of clinical investigation
- 1 May 2000
Induction of myelin-specific CD4 T cells is a pivotal event in the development of experimental autoimmune encephalomyelitis (EAE). Other checkpoints in EAE pathogenesis have not been clearly defined,… Expand
c-kit+ Cardiac Stem Cells Alleviate Post-Myocardial Infarction Left Ventricular Dysfunction Despite Poor Engraftment and Negligible Retention in the Recipient Heart
Although transplantation of c-kit+ cardiac stem cells (CSCs) has been shown to alleviate left ventricular (LV) dysfunction induced by myocardial infarction (MI), the number of exogenous CSCs… Expand