Y. Guo

Publications48
h-index21
Citations1,754
Highly Influential Citations39
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Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.
TLDR
Histologic examination of tumor tissue showed that consumption of soy products significantly reduced tumor cell proliferation, increased apoptosis and reduced microvessel density, and the data suggest that dietary soy products may inhibit experimental prostate tumor growth through a combination of direct effects on tumors cells and indirect effects on tumor neovasculature.
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Racial differences in prostate cancer growth: Apoptosis and cell proliferation in Caucasian and African‐American patients
TLDR
Assessment of the incidence of apoptosis and cell proliferation in prostate cancer specimens from African‐American and Caucasian patients in an attempt to identify potential differences in tumor growth determinants between the two ethnic groups.
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Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer
TLDR
It is demonstrated that metformin stimulates increased expression of miR-708-5p to target the NNAT-mediated response to ER stress and apoptosis, leading to suppression of endoplasmic reticulum (ER) membrane protein neuronatin (NNAT) expression and subsequently induces apoptosis of prostate cancer cells through the ER stress pathway.
View on Nature
Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells.
  • Y. Guo, N. Kyprianou
  • Biology, Medicine
    Cell growth & differentiation : the molecular…
  • 1 February 1998
TLDR
The results indicate that overexpression of TGF-beta1 R-II receptor in LNCaP prostate cancer cells caused tumor growth inhibition by restoring the T GF-beta signaling mechanism and TGF -beta1 sensitivity.
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Regulation of prostate‐specific antigen gene expression in LNCaP human prostatic carcinoma cells by growth, dihydrotestosterone, and extracellular matrix
TLDR
The results indicate that the morphology and proliferation of LNCaP cells may be regulated by the ability of ECM to control cellular differentiation and proliferation.
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Analysis of circulating miRNAs 21 and 375 as potential biomarkers for early diagnosis of prostate cancer.
To investigate the diagnostic potential of plasma miR-21 and miR-375 by comparing their levels in prostate cancer (PCa) patients to subjects without cancer in a Chinese population. The study…
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Transient suppression of X-ray-induced apoptosis by exposure to power frequency magnetic fields in MCF-7 cells.
TLDR
Exposure to 60-Hz MFs has no effects on the growth of MCF-7 cells, but it might transiently suppress X-ray-induced apoptosis through increasing the Bcl-2/Bax ratio.
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Overexpressed miR-155 is associated with initial presentation and poor outcome in Chinese pediatric acute myeloid leukemia.
  • L-H Xu, Y. Guo, S-Y Hu
  • Biology, Medicine
    European review for medical and pharmacological…
  • 1 December 2015
TLDR
Findings suggested that miR-155 expression cannot only be promising biomarker for the early detection of pediatric AML but also predict poor outcome.
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Glutathione S-transferase M1, T1 status and the risk of head and neck cancer: a meta-analysis
TLDR
A number of studies have confirmed or refuted an association between GSTM1 or GSTT1 deficiency and head and neck cancer, and suggested individuals who lack these genes are more likely to develop cancer than those who have these genes, because of their inability to detoxify carcinogenic chemicals.
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Loss of the cyclin-dependent kinase inhibitor p27(Kip1) protein in human prostate cancer correlates with tumor grade.
TLDR
Results indicate that frequent loss of the cyclin-dependent kinase inhibitor p27(Kip1) in human prostate cancer cells correlates with advancing histological aggressiveness, implicating deregulation of p27 (Kip 1) in prostate tumor progression.
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