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Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
Eukaryotic cells store neutral lipids in cytoplasmic lipid droplets enclosed in a monolayer of phospholipids and associated proteins. These dynamic organelles serve as the principal reservoirs forExpand
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Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
  • L. Shen, M. Toyota, +9 authors J. Issa
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 20 November 2007
Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this view does not fully reflect the molecular heterogeneity of the disease.Expand
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Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong.
Analysis of the sequences of all eight RNA segments of the influenza A/G oose/Guangdong/1/96 (H5N1) virus, isolated from a sick goose during an outbreak in Guangdong province, China, in 1996,Expand
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Structure and Function of Flavivirus NS5 Methyltransferase
ABSTRACT The plus-strand RNA genome of flavivirus contains a 5′ terminal cap 1 structure (m7GpppAmG). The flaviviruses encode one methyltransferase, located at the N-terminal portion of the NS5Expand
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A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the
ABSTRACT The few antibodies that can potently neutralize human immunodeficiency virus type 1 (HIV-1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious virions.Expand
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The Lipid-Droplet Proteome Reveals that Droplets Are a Protein-Storage Depot
BACKGROUND Lipid droplets are ubiquitous organelles that are among the basic building blocks of eukaryotic cells. Despite central roles for cholesterol homeostasis and lipid metabolism, theirExpand
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DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.
PURPOSE The current classification systems of myelodysplastic syndromes (MDS), including the International Prognostic Scoring System (IPSS), do not fully reflect the molecular heterogeneity of theExpand
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Lipid droplets at a glance
Lipid droplets (LDs) are the major cellular organelles for the storage of neutral lipids. Excessive lipid storage in LDs is central to the pathogenesis of prevalent metabolic diseases, such asExpand
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Differential Inhibition of Human Immunodeficiency Virus Type 1 Fusion, gp120 Binding, and CC-Chemokine Activity by Monoclonal Antibodies to CCR5
ABSTRACT The CC-chemokine receptor CCR5 mediates fusion and entry of the most commonly transmitted human immunodeficiency virus type 1 (HIV-1) strains. We have isolated six new anti-CCR5 murineExpand
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Structures of a Na+-coupled, substrate-bound MATE multidrug transporter
Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE) family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a preexisting Na+ orExpand
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