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atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system
TLDR
It is found that ectopic expression of the ASC genes promotes external sense organ formation exclusively, whereas ato promotes chordotonal organ formation preferentially, indicating that proneural genes are major determinants of neuronal identity. Expand
Cloning and Functional Expression of a DrosophilaMetabotropic Glutamate Receptor Expressed in the Embryonic CNS
TLDR
The cloning and functional characterization of an invertebrate metabotropic glutamate receptor isolated from Drosophila melanogaster indicates that the original structural features of both glutamate receptor types are conserved from insects to mammals and suggest that the functions of these receptors have been highly conserved during evolution. Expand
Shaggy, the Homolog of Glycogen Synthase Kinase 3, Controls Neuromuscular Junction Growth in Drosophila
TLDR
Drosophila homolog of the mammalian glycogen synthase kinases 3 α and β, two serine-threonine kinases, was concentrated at this synapse and it was found that Shaggy negatively controlled the NMJ growth. Expand
Glutamate and its metabotropic receptor in Drosophila clock neuron circuits
TLDR
It is shown that glutamate and its metabotropic receptor, DmGluRA, are components of the clock circuitry and modulate the rhythmic behavior pattern of Drosophila. Expand
The Drosophila Metabotropic Glutamate Receptor DmGluRA Regulates Activity-Dependent Synaptic Facilitation and Fine Synaptic Morphology
TLDR
It is shown here that DmGluRA is expressed at the glutamatergic neuromuscular junction (NMJ), localized in periactive zones of presynaptic boutons but excluded from active sites, and the following two roles are revealed: modulation of Presynaptic excitability properties important for the control of activity-dependent neurotransmitter release and modulation of synaptic architecture. Expand
Dual Mechanism for Bitter Avoidance in Drosophila
TLDR
It is postulate that sugar-sensing inhibition represents a mechanism in insects to prevent ingesting harmful substances occurring within mixtures and that it affects taste cells on the proboscis and the legs. Expand
Muscle Dystroglycan Organizes the Postsynapse and Regulates Presynaptic Neurotransmitter Release at the Drosophila Neuromuscular Junction
TLDR
A conservation of DGC composition and interactions between Drosophila and vertebrates at the synapse is illustrated, new proteins associated with this complex are highlighted and an unsuspected trans-synaptic function of Dg is suggested. Expand
Plant Insecticide L-Canavanine Repels Drosophila via the Insect Orphan GPCR DmX
TLDR
These findings show that the DmX receptor, which does not belong to the Gr family, fulfills a gustatory function necessary to avoid eating a natural toxin. Expand
Divergent Evolution in Metabotropic Glutamate Receptors
TLDR
It is found that the DmX receptor was activated by a ligand containing an amino group, which was extracted from Drosophila head and from other insects (Anopheles and Schistocerca) and indicates that the LBP of the mGluRs has diverged in insects to recognize a new ligand. Expand
An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.
TLDR
A transcription unit of approximately 40 kb lying within the cloned chromosomal interval 3B1 is described, and evidence that it encodes the sgg+ function is provided, revealing that the protein kinase domain of sgg is distantly related to the members of the CDC28/cdc2+ subfamily of protein kinases, all of which play cardinal roles in the regulation of the yeast and mammalian cell cycles. Expand
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