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Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
Imprinted genes are clustered in domains, and their allelic repression is mediated by imprinting control regions. These imprinting control regions are marked by DNA methylation, which is essential toExpand
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Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy
Significance Circular dichroism (CD) spectroscopy is widely used for protein secondary structure analysis. However, quantitative estimation for β-sheet–containing proteins is problematic due to theExpand
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A toxic monomeric conformer of the polyglutamine protein
Polyglutamine (polyQ) diseases are classified as conformational neurodegenerative diseases, like Alzheimer and Parkinson diseases, and they are caused by proteins with an abnormally expanded polyQExpand
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The organization of histone H3 modifications as revealed by a panel of specific monoclonal antibodies.
Histone modifications play critical roles in the epigenetic regulation of gene expression and in the maintenance of genome integrity. Acetylation and methylation of histone H3 are particularlyExpand
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Allele‐specific histone lysine methylation marks regulatory regions at imprinted mouse genes
In different eukaryotic model systems, chromatin and gene expression are modulated by post‐translational modification of histone tails. In this in vivo study, histone methylation and acetylation areExpand
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Protein folding by the effects of macromolecular crowding
Unfolded states of ribonuclease A were used to investigate the effects of macromolecular crowding on macromolecular compactness and protein folding. The extent of protein folding and compactness wereExpand
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Clustering of Fluorine-Substituted Alcohols as a Factor Responsible for Their Marked Effects on Proteins and Peptides
Among various alcohols, those substituted with fluorine, such as 2,2,2-trifluoroethanol (TFE) or 3,3,3,3‘,3‘,3‘-hexafluoro-2-propanol (HFIP), have a marked potential to induce the formation ofExpand
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Solution structure and dynamics of bovine β‐lactoglobulin A
Using heteronuclear NMR spectroscopy, we studied the solution structure and dynamics of bovine β‐lactoglobulin A at pH 2.0 and 45 °C, where the protein exists as a monomeric native state. TheExpand
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Site-specific analysis of histone methylation and acetylation.
Covalent modifications on the nucleosomal histones are essential in chromatin regulation and gene expression. Patterns of histone modifications may be somatically maintained and can thereby maintainExpand
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Effect of methanol concentration on the production of human β2-glycoprotein I domain V by a recombinant Pichia pastoris: A simple system for the control of methanol concentration using a
Abstract The methylotrophic yeast Pichia pastoris is one of the best hosts for the production of foreign proteins because of the presence of the strong AOX1 promoter induced by methanol. MethanolExpand
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