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Structural basis for recognition of 2′,5′‐linked oligoadenylates by human ribonuclease L
An interferon‐induced endoribonuclease, ribonuclease L (RNase L), is implicated in both the molecular mechanism of action of interferon and the fundamental control of RNA stability in mammalianExpand
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Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
ER aminopeptidase 1 (ERAP1) customizes antigenic peptide precursors for MHC class I presentation and edits the antigenic peptide repertoire. Coding single nucleotide polymorphisms (SNPs) in ERAP1Expand
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Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis.
Epidermal cell differentiation inhibitor (EDIN) is a recently discovered protein which inhibits terminal differentiation of cultured keratinocytes (Sugai, M., Enomoto, T., Hashimoto, K., Matsumoto,Expand
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Reduced activity of the hypertension‐associated Lys528Arg mutant of human adipocyte‐derived leucine aminopeptidase (A‐LAP)/ER‐aminopeptidase‐1
The adipocyte‐derived leucine aminopeptidase (A‐LAP)/ER aminopeptidase‐1 is a multi‐functional enzyme belonging to the M1 family of aminopeptidases. It was reported that the polymorphism Lys528Arg inExpand
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Enzymatic Properties of Human Aminopeptidase A
Aminopeptidase A (APA) is a type II membrane-bound protein implicated in the regulation of blood pressure in the brain renin-angiotensin system. In this study, a recombinant soluble form of APA wasExpand
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Angiotensinogen-deficient mice with hypotension.
The renin-angiotensin system is an enzymatic cascade that produces a potent vasoconstrictor octapeptide angiotensin II, through its physiologically inactive intermediate decapeptide angiotensin I,Expand
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Iron uptake and regulation of ferritin synthesis by hepatoma cells in hormone-supplemented serum-free media.
Iron, as ferric nitrilotriacetate or ferric ammonium citrate, was administered to rat hepatoma cells (H4AZC2) that were grown in serum-containing media or in hormone-supplemented defined media onExpand
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Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes.
mtDNA with a point mutation in the tRNA(Ile) gene at nucleotide position 4269 found in a patient with fatal cardiomyopathy and mtDNA with a point mutation in the tRNA(Arg) gene at 10410 found in aExpand
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Laeverin/Aminopeptidase Q, a Novel Bestatin-sensitive Leucine Aminopeptidase Belonging to the M1 Family of Aminopeptidases*
Laeverin/aminopeptidase Q (APQ) is a cell surface protein specifically expressed on human embryo-derived extravillous trophoblasts that invades the uterus during placentation. The cDNA cloning ofExpand
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2‐5A induces a conformational change in the ankyrin‐repeat domain of RNase L
RNase L is responsible for the 2‐5A host defense system, an RNA degradation pathway present in cells of higher vertebrates that functions in both the antiviral and anticellular activities ofExpand
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