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Genome-wide association study identifies a novel breast cancer susceptibility locus at 6q25.1
We carried out a genome-wide association study among Chinese women to identify risk variants for breast cancer. After analyzing 607,728 SNPs in 1,505 cases and 1,522 controls, we selected 29 SNPs forExpand
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Meta-analysis identifies common variants associated with body mass index in East Asians
Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. WeExpand
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Lung cancer among Chinese women
A case‐control stud/involving interviews with 672 female lung cancer patients and 735 population‐based controls was conducted to investigate the high rates of lung cancer, notably adenocarcinoma,Expand
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus inExpand
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Association of menstrual and reproductive factors with breast cancer risk: Results from the Shanghai breast cancer study
The incidence of breast cancer among women in Shanghai, a traditionally low‐risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual andExpand
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Effects of reproductive and demographic changes on breast cancer incidence in China: a modeling analysis.
BACKGROUND Breast cancer incidence is currently low in China. However, the distribution of reproductive and lifestyle risk factors for breast cancer among Chinese women is changing rapidly. WeExpand
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Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China
BACKGROUND Dietary isothiocyanates inhibit lung carcinogenesis in laboratory animals but human data are limited. Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanatesExpand
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Reduced risk of esophageal cancer associated with green tea consumption.
BACKGROUND Studies in laboratory animals have suggested inhibitory effects of green tea on the induction of some cancers, notably, esophageal cancer. However, only a few epidemiologic studies haveExpand
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Association of cyclin D1 genotype with breast cancer risk and survival.
Cyclin D1 (CCND1) is a key cell cycle regulatory protein that governs cell cycle progression from the G(1) to S phase. A common polymorphism (A870G) in exon 4 of the CCND1 gene produces an alternateExpand
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Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study.
  • Q. Cai, X. Shu, +5 authors W. Zheng
  • Biology, Medicine
  • Cancer epidemiology, biomarkers & prevention : a…
  • 1 September 2003
Estrogen receptor (ER) is a ligand-activated transcription factor that mediates estrogen actions in target tissues. Several common polymorphisms of the ER-alpha gene have been reported to beExpand
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