Y. -G. Qu

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By the use of [1H,15N] heteronuclear single quantum coherence (HSQC) 2D NMR spectroscopy and electrochemical methods we have determined the hydrolysis profile of the bifunctional dinuclear platinum(More)
The novel phase II anticancer drug BBR3464 ([{trans-PtCl(NH3)2}2-µ-{trans-Pt(NH3)2(NH2(CH2)6NH2)2}](NO3)4) forms a 1,4-interstrand cross-link adduct with the self-complementary DNA octamer(More)
The synthesis of two new isomeric trifunctional dinuclear platinum complexes of formula [¿PtCl(NH(3))(2)¿micro-NH(2)(CH(2))(6)NH(2)-¿PtCl(2)(N H(3))¿](+) (1, 2/c,c and 1,2/t,c) is reported. Their(More)
Reported here is a detailed study of the kinetics and mechanism of formation of a 1,4 GG interstrand cross-link by [(trans-PtCl(NH(3))(2))(2)(mu-NH(2)(CH(2))(n)NH(2))](2+) (1,1/t,t (n = 6), 1), the(More)