• Publications
  • Influence
Characterization of sialosylated Lewisx as a new tumor-associated antigen.
Results indicate that the CSLEX1 epitope has the following structure: These results indicate that this structure had not previously been known to be tumor associated. Expand
Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6).
The hybridoma (FH6) secreting a monoclonal IgM antibody directed to this glycolipid was selected by reactivity of the antibody with this ganglioside and lack of reactivity with other Glycolipids having a closely related structure. Expand
Quantitative and qualitative characterization of human cancer-associated serum glycoprotein antigens expressing fucosyl or sialyl-fucosyl type 2 chain polylactosamine.
The serum level of the antigen, defined by monoclonal antibody FH6 (termed sialyl LeX-i since this determinant is carried by i antigen), was significantly high in patients with cancers originating from organs from which adenocarcinomas often develop, as well as among various types of lung cancer. Expand
Location and distribution of difucoganglioside (VI3NeuAcV3III3Fuc2nLc6) in normal and tumor tissues defined by its monoclonal antibody FH6.
The antigen level was found to be significantly higher in the serum of some patients with cancer, particularly lung, liver, and pancreatic cancers, as compared with the serum levels in other types of cancer, noncancerous diseases, and normal subjects. Expand
Expression of LewisX and sialylated LewisX antigens in human colorectal polyps.
Extended LeX antigens and their sialylated derivatives are cancer-associated antIGens that are expressed preferentially in premalignant colon polyps that tend to correlate with malignant potential in these polyps, and that may eventually help to define mechanisms involved in the polyp-to-cancer sequence. Expand
Novel Fucolipids Accumulating in Human Adenocarcinoma
A series of glycolipids having the X determinant (Gal~1+4[Fuccr1+3]GlcNAc) at the terminus and a fucosyl a143 residue at the internal GlcNAc residue have been isolated and characterized from tumorExpand
Novel fucolipids accumulating in human adenocarcinoma. II. Selective isolation of hybridoma antibodies that differentially recognize mono-, di-, and trifucosylated type 2 chain.
Two monoclonal antibodies, FH2 and FH3, do not discriminate among various glycolipids having fucosylated type 2 chain, and their reactivities are essentially similar to previously established antibodies directed to the X determinant. Expand
Lewisx- and sialylated Lewisx-related antigen expression in human malignant and nonmalignant colonic tissues.
Six monoclonal antibodies recognizing long-chain polyfucosylated and sialylated LeX-related antigens appear to be useful tools for detection of colon cancer. Expand
Coordinate expression of X and Y haptens during murine embryogenesis.
The results suggest that embryonic cell surface carbohydrate phenotypes represent a balance in the competition between glycosyltransferases for available substrates and rapid changes in carbohydrate expression during development may reflect intermediate states of cellular commitment and determination that are critical for lineage formation and morphogenesis. Expand
A novel disialoganglioside (IV3NeuAcIII6NeuAcLc4) of human adenocarcinoma and the monoclonal antibody (FH9) defining this disialosyl structure.
This gangliosideside is highly immunogenic, and immunization of mice with this disialoganglioside fraction coated on Salmonella minnesota resulted in the establishment of a hybridoma secreting immunoglobulin G2a antibody FH9 that reacts specifically with the gang lioside antigen above. Expand