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Guidelines for the Management of Helicobacter pylori Infection in Japan: 2009 Revised Edition
Background:  Over the past few years, the profile of Helicobacter pylori infection has changed in Japan. In particular, the relationship between H. pylori and gastric cancer has been demonstratedExpand
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Dietary Risk Factors for Inflammatory Bowel Disease: A Multicenter Case‐Control Study in Japan
&NA; To evaluate the role of dietary factors in the etiology of inflammatory bowel disease (IBD), we conducted a multicenter hospital‐based case‐control study in a Japanese population. Cases were IBDExpand
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A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.
BACKGROUND & AIMS Interleukin-6 (IL-6) regulates immune response and inflammation. We carried out a pilot placebo-controlled study to investigate the efficacy, pharmacokinetics, and safety of MRA, aExpand
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Lack of common NOD2 variants in Japanese patients with Crohn's disease.
BACKGROUND & AIMS Previous studies have linked Crohn's disease (CD) to the pericentromeric region of chromosome 16 (IBD1). Three independent studies of Western populations have recently shown that 3Expand
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Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
Sickness evokes various neural responses, one of which is activation of the hypothalamo–pituitary–adrenal (HPA) axis. This response can be induced experimentally by injection of bacterialExpand
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A Multicenter, Double‐Blind Study on Triple Therapy with Lansoprazole, Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori in Japanese Peptic Ulcer Patients
Two triple therapies with lansoprazole (LPZ)/amoxicillin (AMPC)/clarithromycin (CAM) for eradication of Helicobacter pylori were studied in multicenter, double‐blind fashion to evaluate theExpand
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Gastroduodenitis associated with ulcerative colitis
BackgroundUlcerative colitis (UC) is regarded as confined to the colorectum; however, there are several case reports showing upper gastrointestinal involvement. The aim of this study was to examineExpand
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Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: a randomized, controlled trial
Objectives Although an elemental diet has been established as the primary treatment for patients with Crohn's disease, the influence of dietary fat on the elemental diet remains unclear. We haveExpand
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Disruption of the p16/Cyclin D1/Retinoblastoma Protein Pathway in the Majority of Human Hepatocellular Carcinomas
p16, cyclin D1 and retinoblastoma protein (pRB) regulate G1 to S transition and are commonly targeted in various cancers. However, few studies have simultaneously examined all components of theExpand
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Association Between Il‐18 Gene Promoter Polymorphisms and Inflammatory Bowel Disease in a Japanese Population
Background: Interleukin‐18 (IL‐18) is a pleiotropic cytokine that induces the production of interferon (IFN)‐&ggr; and also to regulate Th2 cytokines. Recently, association studies between IL‐18 geneExpand
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