Increased expression of interleukin 17 in inflammatory bowel disease
It is likely that IL-17 expression in IBD may be associated with altered immune and inflammatory responses in the intestinal mucosa and increased in patients with inflammatory bowel disease.
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.
IL-22 derived from activated T cells acts on SEMFs to elicit expression of proinflammatory cytokines and matrix-degrading molecules indicating proinflammatory/remodeling roles in IBD.
Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis
IL-33, derived from colonic SEMFs, may play an important role in the pathophysiology of UC, and is characterized by real-time polymerase chain reaction (PCR) and immunohistochemical methods.
Cross-sectional imaging in Crohn disease.
CT or MR imaging should be included in a comprehensive evaluation of patients with Crohn disease, along with conventional imaging and clinical and laboratory tests, thereby aiding in treatment planning.
Expression of IL-24, an Activator of the JAK1/STAT3/SOCS3 Cascade, Is Enhanced in Inflammatory Bowel Disease
IL-24 derived from colonic SEMFs acts on colonic epithelial cells to elicit JAK1/STAT-3 activation and the expression of SOCS3 and mucins, supporting their suppressive effects on mucosal inflammation in IBD.
Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II.
Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis
The gut microbiota of patients with inactive UC tended to be closer to that of healthy individuals, suggesting different roles for the fecal microbiota in the pathophysiology of UC and CD.
Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease
Dysbiosis in CD patients was shown by a multi-IBD center study and a logistic model to predict disease activity based on the fecal microbiota composition was developed, which proposed the feasibility of using the feces profile as a predictive marker for disease activity.
Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
Epithelial IL-32alpha expression was increased in IBD patients, and in CD patients in particular, and might be involved in the pathophysiology of IBD as a proinflammatory cytokine and a mediator of innate immune response.
Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease
- Takehide Fujimoto, H. Imaeda, A. Andoh
- MedicineJournal of Gastroenterology and Hepatology
- 1 April 2013
This study investigated the abundance of Faecalibacterium prausnitzii, as well as Bilophila wadsworthia, in the gut microbiota of Japanese CD patients to investigate Dysbiosis.