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Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells.
Results indicate that AM, acting as an autocrine/paracrine regulator, exerts an antiproliferative action on EC and MC, and suggest its role as a local modulator of endothelial and mesangial function.
Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.
- Y. Kiso, H. Matsumoto, S. Mizumoto, T. Kimura, Y. Fujiwara, K. Akaji
- Chemistry, BiologyBiopolymers
A novel class of HIV protease inhibitors containing an unnatural amino acid, (2S, 3S)-3-amino-2-hydroxy-4-phenylbutyric acid, named allophenylnorstatine, with a hydroxymethylcarbonyl (HMC) isostere is designed and synthesized.
Disulfide Bond Formation Using the Silyl Chloride-Sulfoxide System for the Synthesis of a Cystine Peptide
- K. Akaji, T. Tatsumi, Makoto Yoshida, Tooru Kimura, Y. Fujiwara, Y. Kiso
- Chemistry, Biology
- 1 May 1992
This new disulfide bond forming reaction in trifluoroacetic acid is successfully applied to the syntheses of oxytocin, human brain natriuretic peptide, and somatostatin without any solubility problem.
Synthesis of cystine-peptide by a new disulphide bond-forming reaction using the siiyl chloride–sulphoxide system
Methyltrichlorosilane or tetrachlorosilane in trifluoroacetic acid, in the presence of diphenylsulphoxide, is found to cleave various S-protecting groups of cysteine to form cystine directly by the…
Synthesis of porcine brain natriuretic peptide-32 using silver tetrafluoroborate as a new deprotecting reagent of the S-trimethylacetamidomethyl group.
Newly isolated porcine brain natriuretic peptide-32 (pBNP-32) was synthesized using AgBF4 and Cys(Tacm) derivatives and had the highest chick rectum relaxant activity among the ANP-BNP families.
Racemization-free synthesis of C-terminal cysteine-peptide using 2-chlorotrityl resin.
The effects of bases, resins, and S-protecting groups on the extent of racemization at the C-terminal cysteine during Fmoc-based solid phase peptide synthesis were investigated.
Solution-phase synthesis of porcine brain natriuretic peptide (pBNP) using S-trimethylacetamidomethylcysteine.
- Y. Kiso, M. Yoshida, T. Kimura, Y. Fujiwara, M. Shimokura, K. Akaji
- Chemistry, BiologyChemical & pharmaceutical bulletin
- 25 May 1990
The hexadodecapeptide corresponding to the entire amino acid sequence of porcine brain natriuretic peptide (pBNP) was synthesized by assembling four segments in solution, followed by HF deprotection…
Deprotection of the S-trimethylacetamidomethyl (Tacm) group using silver tetrafluoroborate: application to the synthesis of porcine brain natriuretic peptide-32 (pBNP-32).
A newly isolated porcine brain natriuretic peptide-32 (pBNP-32) was synthesized by the combined use of the S-Tacm group and AgBF4 deprotection, and the recently developed reagent tetrafluoroboric acid (HBF4) was applied to cleave the peptide from the resin.
Anchoring of Fmoc amino acid to 4-alkoxybenzyl alcohol resin using a new esterification reagent
Fluoren-9-ylmethyloxycarbonyl (Fmoc) amino acid chloride as an efficient reagent for anchoring Fmoc amino acid to 4-alkoxybenzyl alcohol resin.
Esterification of Fmoc amino acids to 4-alkoxybenzyl alcohol polystyrene through acid chlorides was achieved in high yield with practically no racemization. This reaction is especially effective for…