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Development of an optimized backbone of FRET biosensors for kinases and GTPases
We report an optimized backbone for the rapid development of a highly sensitive intramolecular fluorescence resonance energy transfer (FRET) biosensor, which includes an optimized pair of fluorescent
Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin
By visualising the cell cycle, this study found that SPREADs were associated with G2/M cell cycle progression and provided new insights into how cell proliferation and transient ERK activity are synchronised in a living tissue.
Islands under islands: The phylogeography and evolution of Halocaridina rubra Holthuis, 1963 (Crustacean: Decapoda: Atyidae) in the Hawaiian archipelago
The genetic structure and evolutionary history of an endemic anchialine species, the shrimp Halocaridina rubra Holthuis, 1963, was investigated across its range in the Hawaiian archipelago using mitochondrial (e.g., cytochrome oxidase subunit I and large subunit ribosomal) gene sequences.
The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf*
It is proposed that Shoc2 regulates the spatio-temporal patterns of the Ras-ERK signaling pathway primarily by accelerating the Ras -Raf interaction.
Induced metamorphosis in crustacean y-larvae: Towards a solution to a 100-year-old riddle
It is concluded that adult Facetotecta are endoparasitic in still to be identified marine hosts and with a juvenile stage that represents a remarkable convergence to that seen in parasitic barnacles (Crustacea Cirripedia Rhizocephala).
mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells
Live imaging of extracellular signal-regulated kinases (ERK) and mammalian target of rapamycin complex 1 (mTORC 1) activities in oncogenic KRas or BRaf-mutant cancer cells suggested that the suppression of mTORC1 activity and induction of negative regulators of m TORC1 in cancer cells treated for at least 1 day could be used as surrogate markers for the MEKi sensitivity of cancer cells.
Multiple Colonizations Lead to Cryptic Biodiversity in an Island Ecosystem: Comparative Phylogeography of Anchialine Shrimp Species in the Ryukyu Archipelago, Japan
Investigation of genetic variation, population structure, and evolutionary history of three caridean shrimp species in the Ryukyu Archipelago, Japan implies multiple colonizations of the archipelago by the three species, consistent with the center of accumulation hypothesis.
New Records of Four Grapsoid Crabs (Crustacea: Decapoda: Brachyura) from Japan, with Notes on Four Rare Species
Four species of semiterrestrial grapsoid crabs are recorded from Japanese waters for the first time based on material from the Ryukyu Islands. These are: Pachygrapsus planifrons De Man, 1888