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Regenerative medicine legislation in Japan for fast provision of cell therapy products
A new legal framework consisting of three laws for cell‐based and tissue‐based therapies went into effect in November 2014 in Japan and is expected to accelerate safe and fast provision of the innovative products to patients with intractable diseases. Expand
Overview and outlook of Toll-like receptor ligand-antigen conjugate vaccines.
This review introduces the applications of TLR ligands as vaccine adjuvants, focusing on the development of vaccines composed of antigen and TLRligand in single molecules (TLR ligand-antigen conjugates) using Pam3/2Cys, lipid A analogues, recombinant flagellin, imidazoquinoline analogues and unmethylated CpG motifs to activate immune systems. Expand
Development of Potent Bifunctional Endomorphin-2 Analogues with Mixed μ-/δ-Opioid Agonist and δ-Opioid Antagonist Properties
The C terminus of endomorphin-2 (EM-2) analogues (Tyr-Pro-Phe-NH-X) was modified with aromatic, heteroaromatic, or aliphatic groups (X = phenethyl,benzyl, phenyl, naphthyl, pyridyl, quinolyl,Expand
Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes.
Preclinical experiments show that a peptide from the GAS M protein representing a B cell epitope was incorporated alongside a universal T cell helper epitope and a Toll-like receptor 2 targeting lipid moiety to form lipopeptide constructs and could form the basis of an optimal needle-free mucosal GAS vaccine. Expand
Design and Synthesis of Lipopeptide–Carbohydrate Assembled Multivalent Vaccine Candidates Using Native Chemical Ligation
Development of a synthetic vaccine against group A streptococcal infection is increasingly paramount due to the induction of autoimmunity by the main virulent factor – M protein. Peptide vaccines,Expand
Vaccination with Lipid Core Peptides Fails to Induce Epitope-Specific T Cell Responses but Confers Non-Specific Protective Immunity in a Malaria Model
It is demonstrated that vaccination with lipid core peptides fails to induce canonical epitope-specific T cell responses, at least in the authors' rodent model, but can nonetheless confer non-specific protective immunity against Plasmodium parasite challenge. Expand
Recent Advances in Design and Synthesis of Self-Adjuvanting Lipopeptide Vaccines
Recent insights on lipopeptide vaccine research and development are presented, particularly on the influence of the orientation of peptide epitopes and lipids on immune responses, the use of carbohydrates for vaccine targeting, adjuvanting or as peptides carriers, and synthetic approaches to highly pure, multi-epitopic vaccine molecules using native chemical ligation techniques. Expand
The Structure-Activity Relationship of Dmt-NH-X
Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.
Replacement of Tyr(1) by 2',6'-dimethyl-L-tyrosine (Dmt) (9-12) exerted profound effects: [Dmt(1)]EM-2 elevated mu-opioid affinity 4.6-fold yet selectivity fell 330-fold as delta-affinity rose (K(i)delta=28.2 nM). Expand