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Yersinia pestis Endowed with Increased Cytotoxicity Is Avirulent in a Bubonic Plague Model and Induces Rapid Protection against Pneumonic Plague
An important virulence strategy evolved by bacterial pathogens to overcome host defenses is the modulation of host cell death. Previous observations have indicated that Yersinia pestis, the causative… Expand
Interaction of Yersinia pestis with Macrophages: Limitations in YopJ-Dependent Apoptosis
ABSTRACT The enteropathogenic Yersinia strains are known to downregulate signaling pathways in macrophages by effectors of the type III secretion system, in which YopJ/YopP plays a crucial role. The… Expand
The NlpD Lipoprotein Is a Novel Yersinia pestis Virulence Factor Essential for the Development of Plague
Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted. In the present study, we… Expand
Generation of Yersinia pestis Attenuated Strains by Signature-Tagged Mutagenesis in Search of Novel Vaccine Candidates
ABSTRACT In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the causative agent of plague, a signature-tagged mutagenesis strategy was used and optimized for a… Expand
Effective Protective Immunity to Yersinia pestis Infection Conferred by DNA Vaccine Coding for Derivatives of the F1 Capsular Antigen
ABSTRACT Three plasmids expressing derivatives of the Yersinia pestis capsular F1 antigen were evaluated for their potential as DNA vaccines. These included plasmids expressing the full-length F1, F1… Expand
Development of an Improved Selective Agar Medium for Isolation of Yersinia pestis
- R. Ber, E. Mamroud, +4 authors S. Cohen
- Medicine, Biology
- Applied and Environmental Microbiology
- 1 October 2003
ABSTRACT Existing media designed for selective isolation of clinically important members of the genus Yersinia were found to be unsatisfactory for the growth and isolation of Yersinia pestis. We… Expand
Three novel plasmid R6K proteins act in concert to distort DNA within the α and β origins of DNA replication
Three novel R6K genes which are responsible for expression of DNA distortion polypeptides (DDP) were identified. The DDPs act in vivo in concert to induce similar stepwise DNA helix distortions… Expand
The search for early markers of plague: evidence for accumulation of soluble Yersinia pestis LcrV in bubonic and pneumonic mouse models of disease.
- Y. Flashner, M. Fisher, +6 authors S. Cohen
- Biology, Medicine
- FEMS immunology and medical microbiology
- 1 July 2010
Markers of the early stages of plague, a rapidly progressing deadly disease, are crucial for enabling the onset of an effective treatment. Here, we show that V-antigen protein (LcrV) is accumulated… Expand
Alpha and beta replication origins of plasmid R6K show similar distortions of the DNA helix in vivo.
- Y. Flashner, A. Shafferman
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 1990
Plasmid R6K contains inverted repeats of an approximately 100-base-pair sequence separated by 5.5 kilobases. These long inverted repeats (LIRs) occur within the alpha and beta origins of replication… Expand
Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague.
Plague is a life-threatening disease caused by Yersinia pestis, for which effective-licensed vaccines and reliable predictors of in vivo immunity are lacking. V antigen (LcrV) is a major Y. pestis… Expand