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Low-level lead-induced neurotoxicity in children: an update on central nervous system effects
In integrating physiological and clinical data, it may be suggested that the different mechanisms of low level lead neurotoxicity have a final common functional pathway. Expand
Stress-induced activation of the hippocampal cholinergic system and the pituitary-adrenocortical axis
- G. Gilad, Barry D. Mahon, Y. Finkelstein, B. Koffler, V. Gilad
- Medicine, Chemistry
- Brain Research
- 18 November 1985
The results demonstrate that after short term stress the septo-hippocampal cholinergic system is activated secondary to activation of the pituitary-adrenocortical axis and major changes in circulating corticosterone can modulate the activity of the hippocampalCholinergic synapse. Expand
Differential deposition of manganese in the rat brain following subchronic exposure to manganese: a T1-weighted magnetic resonance imaging study.
- Y. Finkelstein, N. Zhang, V. Fitsanakis, M. Avison, J. Gore, M. Aschner
- The Israel Medical Association journal : IMAJ
- 1 November 2008
Prominent Mn depositions, evidenced by T1-weighted hyperintensities in the hippocampus after subacute exposure to Mn, are compatible with the clinical picture of manganism during its early stages, and may explain its pathophysiology. Expand
A pregnant woman with hepatitis A and Guillain-Barré.
- G. Breuer, G. Morali, Y. Finkelstein, J. Halevy
- Journal of clinical gastroenterology
- 1 February 2001
This is the first reported case in the English literature of a triple condition of hepatitis A, GBS, and pregnancy in a pregnant woman. Expand
Impact of integrated pest management (IPM) training on reducing pesticide exposure in Illinois childcare centers.
This survey determined that the training increased the level of confidence, positive attitudes, and implementation of IPM by childcare providers and was motivated primarily by how IPM protects children's health from exposure to pesticides, in which neurotoxic substances may play a major role. Expand
Dynamics of cholinergic synaptic mechanisms in rat hippocampus after stress
After prolonged periods of stress adaptive changes in the cholinergic terminals are expressed by a reduction in choline uptake and an elevation in the number of muscarinic binding sites; and the chronic stress-induced changes are slow to recover. Expand
Selenium neurotoxicity in humans: bridging laboratory and epidemiologic studies.
- M. Vinceti, J. Mandrioli, P. Borella, B. Michalke, A. Tsatsakis, Y. Finkelstein
- Toxicology letters
- 15 October 2014
This work aimed to address the issue of selenium overexposure from a public health perspective, focusing on both laboratory studies and the few epidemiologic human studies available, with emphasis on their methodological strengths and limitations. Expand
Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis?
- M. Vinceti, Ilaria Bottecchi, A. Fan, Y. Finkelstein, J. Mandrioli
- Chemistry, Medicine
- Reviews on environmental health
Despite limitations in the exposure assessment methodologies typically used in human studies, suggestive epidemiological evidence and biologic plausibility for an association between ALS and antecedent overexposure to environmental selenium and pesticides are found. Expand
Modulation of cholinergic systems by manganese.
Experimental and clinical evidence support the notion that cholinergic activity plays a key role in the pathophysiology of manganese-induced neurotoxicity, which involves impairment of emotional response, decline in higher cortical functions and movement disorder, and highlights the importance of studying the role of the CNS cholinerg systems in mangane-mediated neurotoxicity. Expand
Herbal medicine and epilepsy: Proconvulsive effects and interactions with antiepileptic drugs
The use of complementary and alternative medicine is on the rise, including among patients with epilepsy, and since most patients do not inform their physicians that they are taking herbal medicines, health care professionals must initiate a dialogue in order to prevent complications with the combined regimen. Expand