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- Publications
- Influence
Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
- S. W. Chan, C. J. Lim, Y. F. Chong, A. Pobbati, Caixia Huang, W. Hong
- Medicine, Biology
- The Journal of Biological Chemistry
- 11 January 2011
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In this report, we describe an independent… Expand
TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*
- S. W. Chan, C. J. Lim, L. S. Loo, Y. F. Chong, Caixia Huang, W. Hong
- Medicine, Biology
- Journal of Biological Chemistry
- 22 May 2009
The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in invasive breast… Expand
WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ
- S. W. Chan, C. J. Lim, +6 authors W. Hong
- Biology, Medicine
- Oncogene
- 25 October 2010
The transcriptional co-activators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. YAP and TAZ both possess WW domains, which are important protein–protein… Expand
The hippo pathway in biological control and cancer development
- S. W. Chan, C. J. Lim, +4 authors W. Hong
- Biology, Medicine
- Journal of cellular physiology
- 1 April 2011
The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis.… Expand
Abstract LB-17: WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ
- S. W. Chan, C. J. Lim, Caixia Huang, Y. F. Chong, K. Harvey, W. Hong
- Chemistry
- 15 April 2010
The transcriptional co-activators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. YAP and TAZ both possess WW domains which are important protein-protein… Expand