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The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins
We identified a Saccharomyces cerevisiae peroxisomal membrane protein, Pex13p, that is essential for protein import. A point mutation in the COOH-terminal Src homology 3 (SH3) domain of Pex13pExpand
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Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane
We have cloned PEX15 which is required for peroxisome biogenesis in Saccharomyces cerevisiae. pex15Δ cells are characterized by the cytosolic accumulation of peroxisomal matrix proteins containing aExpand
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The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl‐CoA under in vivo conditions.
We investigated how NADH generated during peroxisomal beta‐oxidation is reoxidized to NAD+ and how the end product of beta‐oxidation, acetyl‐CoA, is transported from peroxisomes to mitochondria inExpand
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Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning
We uncovered a role for ERK signaling in GABA release, long-term potentiation (LTP), and learning, and show that disruption of this mechanism accounts for the learning deficits in a mouse model forExpand
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Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses
Mammals can be trained to make a conditioned movement at a precise time, which is correlated to the interval between the conditioned stimulus and unconditioned stimulus during the learning. ThisExpand
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Inhibitory Autophosphorylation of CaMKII Controls PSD Association, Plasticity, and Learning
To investigate the function of the alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) inhibitory autophosphorylation at threonines 305 and/or 306, we generated knockin mice that expressExpand
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Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation Syndrome
Angelman syndrome (AS) is a disorder of human cognition characterized by severe mental retardation and epilepsy. Recently, a mouse model for AS (Ube3a maternal null mutation) was developed thatExpand
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Rapid changes in hippocampal CA1 pyramidal cell function via pre‐ as well as postsynaptic membrane mineralocorticoid receptors
Corticosterone (100 nm) rapidly increases the frequency of miniature excitatory postsynaptic currents in mouse CA1 pyramidal neurons via membrane‐located mineralocorticoid receptors (MRs). We nowExpand
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Analysis of the Carboxyl-terminal Peroxisomal Targeting Signal 1 in a Homologous Context in Saccharomyces cerevisiae*
Most peroxisomal matrix proteins contain a carboxyl-terminal tripeptide that directs them to peroxisomes. Within limits, these amino acids may be varied, without loss of function. The specificity ofExpand
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Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures
Tuberous sclerosis complex (TSC) is characterized by brain lesions, epilepsy, increased incidence of mental retardation and autism. The causal link between lesion load and epilepsy on cognitiveExpand
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