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Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide.
Triggering receptor expressed on myeloid cells-2 (TREM-2) has been shown to attenuate inflammatory responses in various cell lines including bone marrow-derived macrophages, hepatic macrophages,… Expand
Genomic DNA Hypomethylation Is Associated with Neural Tube Defects Induced by Methotrexate Inhibition of Folate Metabolism
DNA methylation is thought to be involved in the etiology of neural tube defects (NTDs). However, the exact mechanism between DNA methylation and NTDs remains unclear. Herein, we investigated the… Expand
Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases.
Matrix metalloproteinases (MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular… Expand
Diabetes Complications Severity Index (DCSI)-Update and ICD-10 translation.
AIMS The Diabetes Complications Severity Index (DCSI) converts diagnostic codes and laboratory results into a 14-level metric quantifying the long-term effects of diabetes on seven body systems.… Expand
Identification of DNA methylation-driven genes in esophageal squamous cell carcinoma: a study based on The Cancer Genome Atlas
BackgroundAberrant DNA methylations are significantly associated with esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the DNA methylation-driven genes in ESCC by… Expand
Impact of TREM-2 gene silencing on inflammatory response of endotoxin-induced acute lung injury in mice
- Dai Liu, Y. Dong, Zhuola Liu, B. Niu, Y. Wang, X. Gao
- Molecular and Cellular Biochemistry
- 11 June 2014
Acute lung injury (ALI) is one of the critical clinical respiratory diseases, of which infection is the main cause and the first risk factor. This study investigated the impact of triggering receptor… Expand
Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression.
- Yuanyong Wang, Rongjian Xu, +17 authors W. Jiao
- Translational lung cancer research
- 1 December 2019
Background Circular RNAs (circRNAs) belong to a new type of endogenous non-coding RNA and plays a key role in carcinogenesis. Circ-ZKSCAN1 (hsa_circ_0001727) has been proven to be a tumor-dependent… Expand
Performance of an Automatic Arrhythmia Classification Algorithm: Comparison to the ALTITUDE Electrophysiologist Panel Adjudications
- D. Mahajan, Y. Dong, +7 authors B. Powell
- Pacing and clinical electrophysiology : PACE
- 1 July 2014
Adjudication of thousands of implantable cardioverter defibrillator (ICD)‐treated arrhythmia episodes is labor intensive and, as a result, is most often left undone. The objective of this study was… Expand
Raltitrexed’s effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation
The causal metabolic pathway and the underlying mechanism between folate deficiency and neural tube defects (NTDs) remain obscure. Thymidylate (dTMP) is catalyzed by thymidylate synthase (TS) using… Expand
Identification of a putative competitive endogenous RNA network for lung adenocarcinoma using TCGA datasets
The mechanisms underlying the oncogenesis and progression of lung adenocarcinoma (LUAD) are currently unclear. The discovery of competitive endogenous RNA (ceRNA) regulatory networks has provided a… Expand