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Development of an ion-pair HPLC method for investigation of energy charge changes in cerebral ischemia of mice and hypoxia of Neuro-2a cell line.
The determination of adenine nucleotides and energy charge (EC) has great importance in the characterization of cerebral ischemic injury and post-ischemic recovery. An IP-HPLC method was developedExpand
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Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract.
In order to investigate the pharmacokinetics of berberine in Coptidis rhizoma extract in rat hippocampus and plasma, a simple and accurate high-performance liquid chromatography method was employedExpand
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The effects of Ananas comosus L. leaves on diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet.
The aim of this study is to demonstrate the effects of Ananas comosus L. leaves on diabetic-dyslipidemic rats. Hypoglycemic and hypolipidemic activities of the ethanolic extract of Ananas comosus L.Expand
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Formulation and Drug Loading Features of Nano-Erythrocytes
Nano erythrocyte ghosts have recently been used as drug carriers of water-soluble APIs due to inherit biological characteristics of good compatibility, low toxicity, and small side-effect. In thisExpand
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The antidepressant effect of ethanol extract of radix puerariae in mice exposed to cerebral ischemia reperfusion
In our pilot study, the depressive-like behaviors of mice exposed to cerebral ischemia reperfusion (CIR) were observed and the antidepressant effects of radix puerariae (RP; root of the PuerariaExpand
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Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats.
The objective of the present study was to investigate the effects of cerebral ischemia-reperfusion on pharmacokinetics of paeoniflorin after intravenous administration of Paeoniae Radix extract (PRE)Expand
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Determination of paeoniflorin in rat hippocampus by high-performance liquid chromatography after intravenous administration of Paeoniae Radix extract.
  • X. He, D. Xing, +4 authors L. Du
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 5 April 2004
A rapid and simple high-performance liquid chromatographic (HPLC) assay for the determination of paeoniflorin in rat hippocampus was developed in this study. The chromatographic analysis was carriedExpand
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Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study
A sensitive and specific liquid-chromatography tandem mass spectrometry (LC-MS/MS) assay has been developed and validated for the simultaneous quantification of ivabradine and its active metaboliteExpand
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[Study on chemical constituents in rhizome of Smilax perfoliate].
OBJECTIVE To investigate the components of Smilax perfoliate. METHOD The chemical components were isolated by solvent extraction and column chromatography. The chemical structures were identifiedExpand
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Chronokinetic study of cefalexin in postprandial and fasting volunteers
Few researches were conducted on the circadian variation of β-lactam antibiotics in humans. The aim of the present study was to determine whether circadian variation of cefalexin pharmacokineticsExpand
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