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Protein kinase C controls lysosome biogenesis independently of mTORC1
It is shown that PKC couples activation of the TFEB transcription factor with inactivation of the ZKSCAN3 transcriptional repressor through two parallel signalling cascades, which suggests PKC activation may mediate lysosomal adaptation to many extracellular cues.
Garmultins A-G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora.
Three compounds were capable of inhibiting oncogene expression and inducing apoptosis in human erythroleukemia cells and were determined by extensive NMR analysis, X-ray crystallography, and electronic circular dichroism calculations.
The Advances in the Limonoid Chemistry of the Meliaceae Family
The Meliaceae family is rich sources of limonoid (meliacin), which are well know for their antifeedant activity and bitterness. Although their existence also could be found in Rutaceae, Cneoraceae,
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
To the authors' knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.
Two new triterpenoid saponins from Gymnema sylvestre.
Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.
Five new benzylphenethylamine alkaloids were isolated from Hosta plantaginea by bioassay-guided fractionation and established by means of extensive spectroscopic methods, and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction.
Three New Indole Alkaloids from the Leaves of Alstonia scholaris
Three new akuamillan-type indole alkaloids, i.e., 5-methoxystrictamine (=methyl (5 beta,16R,19E)-5-methoxyakuammilan-17-oate; 1), methyl