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A long non-coding RNA is required for targeting centromeric protein A to the human centromere
The centromere is a specialized chromatin region marked by the histone H3 variant CENP-A. Although active centromeric transcription has been documented for over a decade, the role of centromericExpand
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Tetrameric Structure of Centromeric Nucleosomes in Interphase Drosophila Cells
Centromeres, the specialized chromatin structures that are responsible for equal segregation of chromosomes at mitosis, are epigenetically maintained by a centromere-specific histone H3 variantExpand
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Chaperone-mediated assembly of centromeric chromatin in vitro.
Every eukaryotic chromosome requires a centromere for attachment to spindle microtubules for chromosome segregation. Although centromeric DNA sequences vary greatly among species, centromeres areExpand
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Cell-Cycle-Dependent Structural Transitions in the Human CENP-A Nucleosome In Vivo
In eukaryotes, DNA is packaged into chromatin by canonical histone proteins. The specialized histone H3 variant CENP-A provides an epigenetic and structural basis for chromosome segregation byExpand
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Tetrameric organization of vertebrate centromeric nucleosomes
Mitosis ensures equal genome segregation in the eukaryotic lineage. This process is facilitated by microtubule attachment to each chromosome via its centromere. In centromeres, canonical histone H3Expand
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Structure, dynamics, and evolution of centromeric nucleosomes
Centromeres are defining features of eukaryotic chromosomes, providing sites of attachment for segregation during mitosis and meiosis. The fundamental unit of centromere structure is the centromericExpand
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Centromeric chromatin: what makes it unique?
Centromeres represent the final frontier of eukaryotic genomes. Although they are defining features of chromosomes--the points at which spindle microtubules attach--the fundamental features thatExpand
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CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells
BackgroundThe histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native CENP-A is often found overexpressed in human cancer cells and a rangeExpand
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Histone variants: the tricksters of the chromatin world.
The eukaryotic genome exists in vivo at an equimolar ratio with histones, thus forming a polymer composed of DNA and histone proteins. Each nucleosomal unit in this polymer provides versatileExpand
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Internal modifications in the CENP-A nucleosome modulate centromeric dynamics
BackgroundPosttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within theExpand
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