• Publications
  • Influence
Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant Enterococci [corrected] and methicillin resistant Staphylococcus aureus.
A new series of short pyrrole tetraamides are described whose submicromolar DNA binding affinity is an essential component for their strong antibacterial activity. This class of compounds is relatedExpand
  • 51
  • 3
CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo
CRA-026440 is a novel, broad-spectrum, hydroxamic acid–based inhibitor of histone deacetylase (HDAC) that shows antitumor and antiangiogenic activities in vitro and in vivo preclinically. CRA-026440Expand
  • 23
  • PDF
A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer
We have investigated DNA binding properties of a dicationic polyamide molecule (GL020924) that has exhibited unique protein displacement and gene regulation activities. Fluorescence, thermal meltingExpand
  • 8
Reinforcement Learning for FX trading
Reinforcement learning (RL) is a branch of machine learning in which an agent learns to act within a certain environment in order to maximize its total reward, which is defined in relationship to theExpand
Factors decomposition of carbon emissions embodied in China's agricultural export
An input-output model is established to calculate the volume of carbon emissions embodied in China's agricultural export and its distribution in China's agricultural sectors during the period ofExpand
Effect of sample compositions on chemical analysis using matrix-assisted laser desorption ionization mass spectrometry
Matrix-assisted laser desorption ionization (MALDI) is an effective ionization technique for mass spectrometry. It take advantages of some unique properties of certain organic chemicals to provideExpand
Influence of Yoga on perimenopausal disturbance of middle-aged women
Objective To explore the influence of Yoga on the perimenopausal disturbance of middleaged women so as to provide reference for carrying out health promotion programs in community.Methods Totals ofExpand
Further Understanding of the Food Safety Problem
Frequent occurrence of food quality and safety proves that it is not effective to solve the Problem only from mechanism and supervision mechanism. Instead, it may expand solution ideas from externalExpand