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Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies.
TLDR
Complications after extrapleural pneumonectomy require a unique approach to management, and mortality can be minimized by early detection and aggressive treatment. Expand
Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers.
TLDR
The aims of this article are to review the most well-studied and efficacious local polymer delivery systems from the last two decades, to examine the rationale for utilizing drug-eluting polymer implants in cancer patients, and to identify the patient cohorts that could most benefit from localized therapy. Expand
Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach.
TLDR
Adding antilymphocyte globulin (ALG) to the TBI/CyP-based conditioning approach reduced the radiation required for engraftment to < or = 300 cGy, and may provide a clinically acceptable approach for the induction of donor-specific transplantation tolerance. Expand
A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriers.
TLDR
It is reported here that durable multilineage mixed allogeneic chimerism and donor-specific transplantation tolerance for skin and primarily vascularized allografts can be achieved across multiple histocompatibility barriers using a nonmyeloablative radiation-based approach. Expand
Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (≤2 cm) non-small cell lung cancer.
TLDR
In wedge resection for small non-small cell lung cancer, increasing the margin distance ≤15 mm significantly decreased the local recurrence risk, with no evidence of additional benefit beyond 15 mm. Expand
Graft Produced Interleukin-6 Functions as a Danger Signal and Promotes Rejection After Transplantation
TLDR
The results suggest the paradigm that graft rejection versus tolerance is determined by a balance between the activation of effector T cells versus immune suppression by regulatory T cells, and that after transplantation, IL-6 functions as a systemic danger signal that overcomes constitutive immune suppression mediated by regulators. Expand
Induction of FoxP3+CD4+25+ Regulatory T Cells Following Hemopoietic Stem Cell Transplantation: Role of Bone Marrow-Derived Facilitating Cells12
TLDR
The transplantation of donor FC may provide an alternative approach to permit clinical SC engraftment and induction of transplantation tolerance in the future. Expand
Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database.
TLDR
Age is an independent predictor of postsurgical survival in NSCLC patients, even after adjustment for significant covariates, and among younger patients undergoing curative surgery, lobectomies are more commonly performed and confer a significant survival benefit over limited resections. Expand
Sentinel lymph node mapping of the pleural space.
TLDR
NIR fluorescence imaging in two species demonstrated that the highest superior mediastinal lymph nodes of station 1 are the SLNs of the pleural space, providing intraoperative feasibility and proof of the concept for identifying lymph nodes communicating with the Pleural space on a patient-specific basis, in real-time, and with high sensitivity. Expand
Factors predicting poor survival after resection of stage IA non-small cell lung cancer.
TLDR
The survival of patients with stage IA non-small cell lung cancer within the United States is significantly worse than survival reported from single-institution studies. Expand
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