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Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.
It is demonstrated that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premisedon oxidative stress.
A Critical Assessment of Chromium in the Environment
This article reviews the emissions, environmental fate and transport, analytical chemistry, uptake and metabolism, toxicology, and human epidemiology of chromium. Chromium is unique among regulated
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles.
This study establishes a framework for developing a comprehensive database of protein corona fingerprints and biological responses for multiple nanoparticle types that can be used to develop quantitative relationships that predict the biological responses to nanoparticles and will aid in uncovered the fundamental mechanisms of nano-bio interactions.
Environmental distribution and transformation of mercury compounds
Abstract Health risk assessments for mercury are subject to uncertainties associated with the prediction of exposure from multiple pathways (air, water, and food). In order to accurately predict
Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials.
A multiparametric, automated screening assay that incorporates sublethal and lethal cellular injury responses to perform high-throughput analysis of a batch of commercial metal/metal oxide nanoparticles (NP) with the inclusion of a quantum dot (QD1) is reported.
Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: an old parameter--new insights.
Applications of this technique include the estimation of association constants and mapping the intermolecular interactions in multicomponent systems as well as investigating aggregation, ion pairing, encapsulation, and the size and structure of labile systems.
Wall effects in laminar flow of fluids through packed beds
A model which accounts for the effect of a confining wall and the resulting voidage variations near it on the flow behavior in packed columns is proposed. The model, which is restricted to columns
Development of structure-activity relationship for metal oxide nanoparticles.
The class probabilities provided by the SVM nano-SAR enabled the construction of decision boundaries with respect to toxicity classification under different acceptance levels of false negative relative to false positive predictions.
Classification NanoSAR development for cytotoxicity of metal oxide nanoparticles.
It is important to recognize that a significantly larger data set would be needed in order to expand the applicability domain and increase the confidence and reliability of data-driven nanoSARs.