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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
TLDR
By interrogating data from a large-scale short hairpin RNA–mediated screen across 390 cancer cell line models, it is found that the viability of MTAP-deficient cancer cells is impaired by depletion of the protein arginine methyltransferase PRMT5. Expand
Effects of follicular fluid supplementation of in-vitro maturation medium on the fertilization and development of equine oocytes after in-vitro fertilization or intracytoplasmic sperm injection.
TLDR
It is suggested that follicular fluid supplementation may improve the maturity of equine cumulus-enclosed oocytes sufficiently for the successful use of ICSI, but not sufficiently for normal sperm-egg interaction occurring during IVF. Expand
Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.
TLDR
The results indicate that the ECPKA expression is an ordered cellular response of a living cell to actively exclude excess intracellular PKA molecules from the cell and may serve as a potential diagnostic and prognostic marker for cancer. Expand
Intracytoplasmic sperm injection (ICSI) versus conventional IVF on abattoir-derived and in vitro-matured equine oocytes.
TLDR
Results indicate that ICSI can be applied successfully to in-vitro matured equine oocytes to increase the fertilization rates and that in vitro cytoplasmic maturation of oocytes issuing from a compact cumulus may not be complete enough to lead to a successful fertilization. Expand
Down modulation of IL‐18 expression by human papillomavirus type 16 E6 oncogene via binding to IL‐18
To understand modulation of a novel immune‐related cytokine, interleukin‐18, by human papillomavirus type (HPV) 16 oncogenes, HaCaT, normal keratinocyte cell line, and C‐33A, HPV‐negative cervicalExpand
Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells1
TLDR
It is suggested that the extracellular HPV 16 E6 and E7 proteins may inhibit IL-18-induced IFN-γ production locally in HPV lesions through inhibition ofIL-18 binding to its α-chain receptor. Expand
Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7.
  • K. Cho, C. Yun, +4 authors A. Chung
  • Biology, Medicine
  • Toxicology and applied pharmacology
  • 1 October 2000
TLDR
Results suggest that PYC can inhibit the expression of the proinflammatory cytokine IL-1 by regulating redox-sensitive transcription factors, and may support the possibility that bioflavonoids including PYC could be used as antiinflammatory and immunosuppressive drugs based on their radical scavenging activities. Expand
Antisense DNAs as multisite genomic modulators identified by DNA microarray
TLDR
It is shown that in a sequence-specific manner, antisense targeted to protein kinase A RIα alters expression of the clusters of coordinately expressed genes at a specific stage of cell growth, differentiation, and activation. Expand
Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency
TLDR
It is shown that depleting p53 and p21, which are barriers to reprogramming, yields a high reprograming efficiency and that Mfn1/2 ablation facilitates the induction of pluripotency through the restructuring of mitochondrial dynamics and bioenergetics. Expand
Biochemical characterization of extracellular cAMP-dependent protein kinase as a tumor marker.
TLDR
The results suggest that ECPKA, out of the context of cAMP regulation, may function as a growth factor promoting cell growth and transformation; thus, it may serve as a tumor biomarker. Expand
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