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Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury
LBP is a novel hepatoprotective agent against NASH caused by abnormal liver metabolic functions and partly modulated through the PI3K/Akt/FoxO1, LKB1/AMPK, JNK/c-Jun and MEK/ERK pathways and the downregulation of transcription factors in the liver. Expand
Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator*
Several lines of evidence suggest that Nck5a interacts with the binding proteins at the hydrophilic face of the amphipathic α-helix, and substitution of Glu157 by glutamine abolishes the peptide's ability to bind to the three Nck 5a-binding proteins without diminishing its Cdk5 binding activity. Expand
Identification of downstream targets of LKB1
The 32th Annual Meeting of the Molecular Biology Society of Japan, Yokohama, Japan, 9-12 December 2009.
Hepatocyte‐specific activation of NF‐κB does not aggravate chemical hepatocarcinogenesis in transgenic mice
Transgenic mice in which a constitutively active form of IKKβ was expressed in a hepatocyte‐specific manner serve as a useful model for studying the role of NF‐κB activation in hepatocarcinogenesis as well as inflammatory and metabolic diseases. Expand
The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase
It is demonstrated for the first time that TAX1BP2 is a novel effector of ATM in DNA damage response and delineated a new mechanism by which ATM stabilizes the tumor suppressor TAX 1BP2. Expand
Reduction in Hepatic Apoptosis Modulated by Garlic Derived S-Allylmercaptocysteine (SAMC) in Non-Alcoholic Fatty Liver Disease Rat Model Through P53-Dependent Pathways
It is shown that an up-regulation of NADPH oxidase via AT1 receptor activation mediates CIH-induced oxidative stress and inflammation in rat adrenal medulla. Expand