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Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
TLDR
Two 2',3'-dideoxy-3'-thiapyrimidine nucleosides were found to be the most potent anti-HBV compounds and both SddC and 5-FSddC should be further evaluated for the treatment of human HBV infection.
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
TLDR
This work characterized and mapped altered drug sensitivity markers of nine HSV pol mutants and sequenced the relevant portions of these mutants to favor a model in which protein folding allows interactions among the four regions to form the substrate and drug binding sites.
Metabolism and mechanism of action of 5-fluorouracil.
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
TLDR
There is a great deal of variability in the chiral specificities of cellular enzymes and how these differences can be exploited in the design of better anti-viral and anticancer drugs is demonstrated.
Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
TLDR
The potential use of phosphorothioate oligos as inhibitors of viral replication is highlighted and these are examples of oligos that are being considered for clinical therapeutic trials and meet some, but not all, of these criteria.
Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.
A guanosine analog, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG), was found to inhibit herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2, cytomegalovirus, and Epstein-Barr virus
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil
TLDR
Considering the potent inhibition of the viral DNA synthesis and the nontoxicity of L-FMAU towards the host DNA synthetic machinery, this compound should be further explored for development as asn anti-HBV drug.
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