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Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
Two 2',3'-dideoxy-3'-thiapyrimidine nucleosides were found to be the most potent anti-HBV compounds and both SddC and 5-FSddC should be further evaluated for the treatment of human HBV infection. Expand
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
This work characterized and mapped altered drug sensitivity markers of nine HSV pol mutants and sequenced the relevant portions of these mutants to favor a model in which protein folding allows interactions among the four regions to form the substrate and drug binding sites. Expand
Metabolism and mechanism of action of 5-fluorouracil.
This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes:Expand
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
There is a great deal of variability in the chiral specificities of cellular enzymes and how these differences can be exploited in the design of better anti-viral and anticancer drugs is demonstrated. Expand
Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
The potential use of phosphorothioate oligos as inhibitors of viral replication is highlighted and these are examples of oligos that are being considered for clinical therapeutic trials and meet some, but not all, of these criteria. Expand
Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.
  • C. Chen, Y. Cheng
  • Biology, Medicine
  • The Journal of biological chemistry
  • 15 July 1989
The mitochondrial toxicity and cell growth inhibition were reversed when ddC was removed and the reduction in cellular content of mitochondrial DNA caused by ddC may partially explain the delayed toxicity observed in acquired immunodeficiency syndrome patients treated with the drug. Expand
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil
Considering the potent inhibition of the viral DNA synthesis and the nontoxicity of L-FMAU towards the host DNA synthetic machinery, this compound should be further explored for development as asn anti-HBV drug. Expand
Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.
A guanosine analog, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG), was found to inhibit herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2, cytomegalovirus, and Epstein-Barr virusExpand
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.
The results suggest that different mutations in the HBV genome have a different impact on its sensitivity to those compounds, and L(-)SddC resistant HBV may also be resistant to PCV, L-FMAU, andL(-)Fd4C. Expand
Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia.
Two forms of deoxythymidine kinase from blast cells of acute myelocytic leukemia were identified by electrophoresis and separated and purified by differential affinity column chromatography which resulted in 2416- and 1634-fold purification of the cytoplasmic and mitochondrial enzymes, respectively. Expand