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Identification of Human Intestinal Alkaline Sphingomyelinase as a Novel Ecto-enzyme Related to the Nucleotide Phosphodiesterase Family*
- R. Duan, T. Bergman, +6 authors Å. Nilsson
- Medicine, Biology
- Journal of Biological Chemistry
- 3 October 2003
Alkaline sphingomyelinase (alk-SMase) hydrolyzes dietary sphingomyelin and generates sphingolipid messengers in the gut. In the present study, we purified the enzyme, identified a part of the amino… Expand
Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice
Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the… Expand
Purification, localization, and expression of human intestinal alkaline sphingomyelinase Published, JLR Papers in Press, April 1, 2003. DOI 10.1194/jlr.M300037-JLR200
Sphingomyelin (SM) metabolism in the gut may have an impact on colon cancer development. In this study, we purified alkaline sphingomyelinase (alk-SMase) from human intestinal content, and studied… Expand
Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.
Alkaline sphingomyelinase (alk-SMase) is a new member of the NPP (nucleotide pyrophosphatase/phosphodiesterase) family that hydrolyses SM (sphingomyelin) to generate ceramide in the intestinal tract.… Expand
Purification, characterization, and expression of rat intestinal alkaline sphingomyelinase.
- Y. Cheng, Å. Nilsson, Elisabeth Tömquist, R. Duan
- Chemistry, Medicine
- Journal of lipid research
- 1 February 2002
Intestinal alkaline sphingomyelinase (SMase) has physiological roles in the digestion of sphingomyelin (SM) and clinical implications in colonic carcinogenesis. In the present work, the enzyme from… Expand
Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats
- D. Andersson, Y. Cheng, R. Duan
- Biology, Medicine
- Journal of Cancer Research and Clinical Oncology
- 29 June 2007
Ursolic acid (UA) is a pentacyclic triterpenoid, with anti-cancer and anti-inflammatory properties. Sphingomyelin (SM) hydrolysis generates lipid messengers regulating cell survival. Earlier studies… Expand
Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells.
Sphingomyelin (SM) metabolism in the gut has been implicated in colonic tumorigenesis. Intestinal alkaline sphingomyelinase (alk-SMase) hydrolyses SM in the intestinal content and at the brush… Expand
Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon.
- Y. Cheng, H. Tauschel, Å. Nilsson, R. Duan
- Biology, Medicine
- Scandinavian journal of gastroenterology
BACKGROUND Ursodeoxycholic acid (UDCA) has been found to inhibit the development of colon carcinoma induced by chemical carcinogens with unidentified mechanisms. Sphingomyelin metabolism has emerged… Expand
Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in GenBank.
- J. Wu, Y. Cheng, C. Palmberg, T. Bergman, Å. Nilsson, R. Duan
- Medicine, Biology
- Biochimica et biophysica acta
- 21 February 2005
Intestinal alkaline sphingomyelinase (alk-SMase) digests sphingomyelin and the process may influence colonic tumorigenesis and cholesterol absorption. We recently identified the gene of human… Expand
Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice.
Dietary fibre and fat affect colonic tumourigenesis and inflammation. Sphingomyelin metabolism may have implications for the pathogenesis of colonic tumours and ulcerative colitis. The present study… Expand