Author pages are created from data sourced from our academic publisher partnerships and public sources.
ralGDS family members interact with the effector loop of ras p21.
- A. Kikuchi, S. Demo, Z. Ye, Y. Chen, L. Williams
- Biology, Medicine
- Molecular and cellular biology
- 1 November 1994
Using a yeast two-hybrid system, we identified a novel protein which interacts with ras p21. This protein shares 69% amino acid homology with ral guanine nucleotide dissociation stimulator (ralGDS),… Expand
Structure of UreG/UreF/UreH Complex Reveals How Urease Accessory Proteins Facilitate Maturation of Helicobacter pylori Urease
- Y. Fong, H. C. Wong, M. H. Yuen, P. H. Lau, Y. Chen, Kam-Bo Wong
- Medicine, Biology
- PLoS biology
- 1 October 2013
Structural and biochemical study of urease accessory protein complex provides mechanistic insights into the delivery of nickel to metalloenzyme urease, an enzyme enabling the survival of Helicobacter… Expand
Molecular cloning and expression of a rat kappa opioid receptor.
At least three types of opioid receptors have been identified in the nervous system. In this paper we report molecular cloning and expression of a rat kappa opioid receptor. PCR was performed on… Expand
The Structure of the AXH Domain of Spinocerebellar Ataxin-1*
- Y. Chen, M. Allen, D. Veprintsev, J. Löwe, M. Bycroft
- Biology, Medicine
- Journal of Biological Chemistry
- 30 January 2004
Spinocerebellar ataxia type 1 is a late-onset neurodegenerative disease caused by the expansion of a CAG triplet repeat in the SCA1 gene. This results in the lengthening of a polyglutamine tract in… Expand
Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat.
- Y. Chen, K. Stott, M. Perutz
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 February 1999
We have constructed mutants of chymotrypsin inhibitor 2 with short glutamine repeats inserted into its inhibitory loop. These mutants oligomerize when expressed in Escherichia coli. The dimer of a… Expand
Assembly of Preactivation Complex for Urease Maturation in Helicobacter pylori
- Y. Fong, H. C. Wong, C. P. Chuck, Y. Chen, H. Sun, Kam-Bo Wong
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 19 October 2011
Background: Maturation of urease is assisted by urease accessory proteins UreE, UreF, UreG, and UreH. Results: Crystal structure of UreF-UreH complex revealed conformational changes of UreF upon… Expand
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1;peer review: 2…
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV All… Expand
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates.
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CL pro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All… Expand
First Glimpse of the Peptide Presentation by Rhesus Macaque MHC Class I: Crystal Structures of Mamu-A*01 Complexed with Two Immunogenic SIV Epitopes and Insights into CTL Escape1
The infection of rhesus macaques (Macaca mulatta) by the SIV is the best animal model for studying HIV infection and for AIDS vaccine development. A prevalent MHC class I allele, Mamu-A*01, is known… Expand
Assembly of the preactivation complex for urease maturation in Helicobacter pylori: Crystal Structure of the UreF/UreH complex
Abstract Colonization of Helicobacter pylori in the acidic environment of the human stomach depends on the neutralizing activity of urease. Activation of apo-urease involves carboxylation of… Expand