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Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes throughExpand
ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors
Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surfaceExpand
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we conducted in situ live cell imaging analysis of LIS1 functionExpand
Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
The prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate gland, yet murineExpand
Organoid Cultures Derived from Patients with Advanced Prostate Cancer
The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3DExpand
Structure of the Protein Phosphatase 2A Holoenzyme
Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and aExpand
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.
Insulin-stimulated GLUT4 translocation is central to glucose homeostasis. Functional assays to distinguish individual steps in the GLUT4 translocation process are lacking, thus limiting progressExpand
Overcoming mutation-based resistance to antiandrogens with rational drug design
The second-generation antiandrogen enzalutamide was recently approved for patients with castration-resistant prostate cancer. Despite its success, the duration of response is often limited. ForExpand
Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
The serine/threonine phosphatase protein phosphatase 2A (PP2A) plays an essential role in many aspects of cellular functions and has been shown to be an important tumor suppressor. The core enzyme ofExpand
The zebrafish Nodal signal Squint functions as a morphogen
Secreted morphogens induce distinct cellular responses in a concentration-dependent manner and act directly at a distance. The existence of morphogens during mesoderm induction and patterning inExpand