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Initial sequencing and analysis of the human genome.
The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence. Expand
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
The diarylthiohydantoins RD162 and MDV3100 are characterized, two compounds optimized from a screen for nonsteroidal antiandrogens that retain activity in the setting of increased androgen receptor expression that appear to be promising candidates for treatment of advanced prostate cancer. Expand
Quantum supremacy using a programmable superconducting processor
Quantum supremacy is demonstrated using a programmable superconducting processor known as Sycamore, taking approximately 200 seconds to sample one instance of a quantum circuit a million times, which would take a state-of-the-art supercomputer around ten thousand years to compute. Expand
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours
It is proposed that GIST arises from ICCs with high levels of endogenous ETV1 expression that, when coupled with an activating KIT mutation, drives an oncogenic ETS transcriptional program. Expand
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer
A novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal tissues is reported, suggesting a novel mechanism of oncogene activation in cancer through de novo alternative transcription initiation. Expand
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse mesenchymal cell-state contexts is identified. Expand
A library of atomically thin metal chalcogenides
Molten-salt-assisted chemical vapour deposition is used to synthesize a wide variety of two-dimensional transition-metal chalcogenides and elaborate how the salt decreases the melting point of the reactants and facilitates the formation of intermediate products, increasing the overall reaction rate. Expand
MMPs, TIMP‐2, and TGF‐β1 in the cancerization of oral lichen planus
Matrix metalloproteinases (MMPs) and transforming growth factor‐β1 (TGF‐β1) are important in many physiological and pathological processes.
DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: A review
It is found that outcome in HNSCC can be predicted to a considerable extent by the presence of tumor cell genetic aberrations and the advantages and challenges of using genome‐wide SNP arrays. Expand
Spliceosomal disruption of the non-canonical BAF complex in cancer
The results implicate the disruption of non-canonical BAF in the diverse cancer types that carry SF3B1 mutations and suggest a mechanism-based therapeutic approach for treating these malignancies. Expand