Y. Chen

Publications96
h-index28
Citations3,680
Highly Influential Citations119
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Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
Monkeys serve as important model species for studying human diseases and developing therapeutic strategies, yet the application of monkeys in biomedical researches has been significantly hindered by… Expand
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Mesenchymal Stern Cells from Adult Human Bone Marrow Differentiate into a Cardiomyocyte Phenotype In Vitro
A method for isolating adult human bone marrow mesenchymal stem cells (MSCs) was established, and the ability of human MSCs to differentiate into cells with characteristics of cardiomyocytes in vitro… Expand
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The Cross Talk Between Protein Kinase A– and RhoA-Mediated Signaling in Cancer Cells
The cross talk between cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and RhoA-mediated signal transductions and the effect of this cross talk on biologic features of human prostate and… Expand
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Hepatocyte growth factor enhances the generation of high-purity oligodendrocytes from human embryonic stem cells.
Generation of homogeneous oligodendrocytes as donor cells is essential for human embryonic stem cell (hESC)-based cell therapy for demylinating diseases. Herein we present a novel method for… Expand
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TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys.
Recent advances in gene editing technology have introduced the potential for application of mutagenesis approaches in nonhuman primates to model human development and disease. Here we report… Expand
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Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know… Expand
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Type II cGMP-dependent Protein Kinase Mediates Osteoblast Mechanotransduction*
Continuous bone remodeling in response to mechanical loading is critical for skeletal integrity, and interstitial fluid flow is an important stimulus for osteoblast/osteocyte growth and… Expand
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Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys
Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant… Expand
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Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells.
Because of their similarity to humans, non-human primates are important models for studying human disease and developing therapeutic strategies. Establishment of chimeric animals using embryonic stem… Expand
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Dissecting Signaling Pathways That Govern Self-renewal of Rabbit Embryonic Stem Cells*
The pluripotency and self-renewal of embryonic stem cells (ESC) are regulated by a variety of cytokines/growth factors with some species differences. We reported previously that rabbit ESC (rESC) are… Expand
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