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Differentiation and transplantation of human embryonic stem cell-derived hepatocytes.
BACKGROUND & AIMS The ability to obtain unlimited numbers of human hepatocytes would improve the development of cell-based therapies for liver diseases, facilitate the study of liver biology, andExpand
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In Situ Capture of Chromatin Interactions by Biotinylated dCas9
Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features, yet the molecular composition of the vast majority of CREs in chromatin remains unknown. Here, we describe aExpand
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Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species.
Penicillium species are fungal pathogens that infect crop plants worldwide. P. expansum differs from P. italicum and P. digitatum, all major postharvest pathogens of pome and citrus, in that theExpand
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Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering.
Cardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cellExpand
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Perinatal Asphyxia Induces Long-Term Changes in Dopamine D1, D2, and D3Receptor Binding in the Rat Brain
We have investigated the long-term effects of 15-16 min or 19-20 min of perinatal asphyxia on D1, D2, and D3 receptors (analyzed by quantitative autoradiography) in the mesotelencephalic dopamineExpand
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Fluorescence-topographic NSOM directly visualizes peak-valley polarities of GM1/GM3 rafts in cell membrane fluctuations** This work was supported by NIH RO1 grants HL64560 (to ZWC) and RR13601 (to
Simultaneous fluorescence-topographic nanoscale imaging of cell-surface molecules in the context of membrane ultra-structures has not been reported. Here, near-field scanning optical microscopyExpand
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Nanofibrous clinical-grade collagen scaffolds seeded with human cardiomyocytes induces cardiac remodeling in dilated cardiomyopathy.
Limited data are available on the effects of stem cells in non-ischemic dilated cardiomyopathy (DCM). Since the diffuse nature of the disease calls for a broad distribution of cells, this studyExpand
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miR-124-3p attenuates MPP+-induced neuronal injury by targeting STAT3 in SH-SY5Y cells
Ample evidence has demonstrated the involvement of microRNAs in Parkinson’s disease pathogenesis. miR-124-3p was reported to be able to improve neural functional recovery. However, the underlyingExpand
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Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease
Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of humanExpand
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Inhibitor of DNA binding proteins: implications in human cancer progression and metastasis.
Inhibitor of DNA binding (ID) proteins are a class of helix-loop-helix (HLH) transcription regulatory factors that act as dominant-negative antagonists of other basic HLH proteins through theExpand
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