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Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
Background Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human life span.… Expand
Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons.
- Chao Ma, Yousheng Shu, +5 authors R. LaMotte
- Chemistry, Medicine
- Journal of neurophysiology
- 1 March 2003
We investigated electrophysiological changes in chronically axotomized and neighboring intact dorsal root ganglion (DRG) neurons in rats after either a peripheral axotomy consisting of an L5 spinal… Expand
Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity
- M. Théry, Victor Racine, +5 authors M. Bornens
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 26 December 2006
Control of the establishment of cell polarity is an essential function in tissue morphogenesis and renewal that depends on spatial cues provided by the extracellular environment. The molecular role… Expand
Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis.
BACKGROUND A previous individual patient data meta-analysis by the Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma (MAC-NPC) collaborative group to assess the addition of chemotherapy to… Expand
Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
- Olivier G. de Jong, M. Verhaar, +6 authors B. W. V. van Balkom
- Biology, Medicine
- Journal of extracellular vesicles
- 1 January 2012
Background: The healthy vascular endothelium, which forms the barrier between blood and the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and inflammation by… Expand
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised…
BACKGROUND The effect of the addition of adjuvant chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma is unclear. We aimed to assess the contribution of… Expand
Overexpression of Monocyte Chemoattractant Protein 1 in the Brain Exacerbates Ischemic Brain Injury and is Associated with Recruitment of Inflammatory Cells
- Y. Chen, J. Hallenbeck, +4 authors S. Vogel
- Journal of cerebral blood flow and metabolism…
- 1 June 2003
Brain cells produce cytokines and chemokines during the inflammatory process after stroke both in animal models and in patients. Monocyte chemoattractant protein 1 (MCP-1), one of the proinflammatory… Expand
MUST: a system for identification of miniature inverted-repeat transposable elements and applications to Anabaena variabilis and Haloquadratum walsbyi.
Transposable elements (TE) are functionally important genetic elements that can move within a genome. Miniature inverted-repeat transposable elements (MITEs) constitute a class of transposable… Expand
SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein–Dependent Apoptotic Pathway
Purpose: To characterize the functional role of SIRT6 in hepatocellular carcinoma (HCC). Experimental Design: The expression of SIRT6 in 60 paired paraffin-embedded HCC tissues and adjacent… Expand
miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling.
Doxorubicin (ADR) is successfully used to treat breast cancer, however, it is often associated with the acquired resistance of breast cancer cells which eliminates the therapeutic efficiency of ADR,… Expand