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Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Here we report a comprehensive characterization of our recently developed inhibitor MM-401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically inhibit MLL1 activityExpand
SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Summary SLX4 interacts with several endonucleases to resolve structural barriers in DNA metabolism. SLX4 also interacts with telomeric protein TRF2 in human cells. The molecular mechanism of theseExpand
Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
  • W. Su, Y. Wang, +15 authors Y. Guan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 15 July 2014
Significance Nonalcoholic fatty liver disease (NAFLD) is a common chronic hepatic disease affecting up to 25% of subjects in the developed world, and represents a progressive illness eventuallyExpand
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specificExpand
NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.
Telomeres employ TRF2 to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), thereby repressing ATM-dependent DNA damage checkpoint responses. How TRF2 prevents MRNExpand
The impact of greenhouse vegetable farming duration and soil types on phytoavailability of heavy metals and their health risk in eastern China.
Heavy metal contamination in vegetables from greenhouse vegetable production (GVP) in China requires major attention. For GVP sustainability at a large regional level, 441 surface GVP soil and 132Expand
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex,Expand
Constitutive versus regulated SNARE assembly: a structural basis
SNARE complex formation is essential for intracellular membrane fusion. Vesicle‐associated (v‐) SNARE intertwines with target membrane (t‐) SNARE to form a coiled coil that bridges two membranes andExpand
YKT6 is a core constituent of membrane fusion machineries at the Arabidopsis trans-Golgi network.
SNARE complex formation is essential for membrane fusion in exocytotic and vacuolar trafficking pathways. Vesicle-associated (v-) SNARE associates with a target membrane (t-) SNARE to form a SNAREExpand
Sustainability assessment of greenhouse vegetable farming practices from environmental, economic, and socio-institutional perspectives in China
To provide growing population with sufficient food, greenhouse vegetable production has expanded rapidly in recent years in China and sustainability of its farming practices is a major concern.Expand