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The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3 ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by neddylationExpand
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CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation
Macrophages play pivotal roles in development, homeostasis, tissue repair and immunity. Macrophage proliferation is promoted by macrophage colony-stimulating factor (M-CSF)-induced Akt signaling;Expand
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Virtual faces as a tool to study emotion recognition deficits in schizophrenia
Studies investigating emotion recognition in patients with schizophrenia predominantly presented photographs of facial expressions. Better control and higher flexibility of emotion displays could beExpand
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Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis
This study investigates the expression of hypoxia-inducible factor-l alpha (HIF-1α) and carbonic anhydrase IX (CAIX) in nasopharyngeal carcinoma (NPC) tissues and their correlation withExpand
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Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy.
A novel pH-sensitive drug delivery system of mesoporous silica nanoparticles (MSNs) which were modified by polydopamine (PDA) for controlled release of cationic amphiphilic drug desipramine (DES) wasExpand
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Clinical Next Generation Sequencing for Precision Medicine in Cancer
Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of humanExpand
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Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
Sox2 is a key transcriptional factor for maintaining pluripotency of stem cells. Sox2 deficiency causes neurodegeneration and impairs neurogenesis. Although the transcriptional regulation of Sox2 hasExpand
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USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
The homeobox transcription factor Nanog has a vital role in maintaining pluripotency and self-renewal of embryonic stem cells (ESCs). Stabilization of Nanog proteins is essential for ESCs. TheExpand
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Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
The importance of macrophage plasticity, albeit being discovered recently, has been highlighted in a broad spectrum of biological processes operative in physiological and pathological environments.Expand
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Doxorubicin-loaded star-shaped copolymer PLGA-vitamin E TPGS nanoparticles for lung cancer therapy
Abstract A doxorubicin-loaded mannitol-functionalized poly(lactide-co-glycolide)-b-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles (DOX-loaded M-PLGA-b-TPGS NPs) were prepared by aExpand
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