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Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.
TLDR
It is demonstrated here that bicarbonate directly stimulates mammalian soluble adenylyl cyclase (sAC) activity in vivo and in vitro in a pH-independent manner, which suggests that bICarbonate regulation of cAMP signaling plays a fundamental role in many biological systems. Expand
A bacterial invasin induces macrophage apoptosis by binding directly to ICE.
TLDR
It is found that IpaB binds directly to ICE and this enzyme is activated during S. flexneri infection and specific inhibitors of ICE prevented Shigella‐induced apoptosis. Expand
Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation.
TLDR
PKA treatment of recombinant AC6 in insect cell membranes results in a selective loss of stimulation by high (>10 nM) concentrations of Galphas, suggesting a mechanism of how isoform selective regulatory diversity can be obtained within conserved regions involved in signal communication. Expand
Lutein and zeaxanthin in the eyes, serum and diet of human subjects.
TLDR
The hypothesis that low concentrations of macular pigment may be associated with an increased risk of AMD is supported. Expand
In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.
TLDR
The results suggest that Ptc normally binds Hh without any help from Smo and hence favor a mechanism of signal transduction in which Hh binds specifically to Ptc and induces a conformational change leading to the release of latent Smo activity. Expand
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
TLDR
Overexpression of IKKbeta (C179A) protects NF-kappaB from inhibition by arsenic, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenite is on the IKK catalytic subunits. Expand
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions
TLDR
Uptake studies using 14C-metformin were in qualitative agreement with those using ASP+, with the exception that a larger reduction in transport capacity was observed for M420del, and potential drug–drug interactions at clinical plasma concentrations of metformin for OCT1-M420del was revealed. Expand
Evaluation of Plasma Lysophospholipids for Diagnostic Significance Using Electrospray Ionization Mass Spectrometry (ESI‐MS) Analyses
TLDR
This ESI‐MS‐based assay allows simultaneous detection and quantitation of all different species of LPAs and LPIs in a sample over a range of at least 5–300 pmol and found that both LPA and LPI were elevated in patients with ovarian cancer. Expand
Apoptosis induced by bacterial pathogens.
TLDR
The understanding of the mechanism of apoptosis induced by bacteria could be important in the development of therapy and prevention of infectious diseases. Expand
Glutathione defense mechanism in liver injury: insights from animal models.
TLDR
A differential hepatic response to distinct profiles of hepatic cellular GSH concentration is revealed and transgenic mouse models with genetic deficiencies in glutamate-cysteine ligase provide interesting new insights regarding pathophysiological functions of GSH in the liver. Expand
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