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Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositolExpand
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Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein*
Latent transforming growth factor β-binding protein 1 (LTBP-1) targets latent complexes of transforming growth factor β to the extracellular matrix, where the latent cytokine is subsequentlyExpand
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Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm
Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene identification. Here, we describe a method for analyzing the cancer genome at a single-cell nucleotide level.Expand
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Evolution of calc-alkaline to alkaline magmatism through Carboniferous convergence to Permian transcurrent tectonics, western Chinese Tianshan
Continuous magmatic activity occurred in the western Chinese Tianshan, Central Asia, from the Carboniferous to the Permian, i.e. before and after the Late Carboniferous amalgamation of Junggar andExpand
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Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity
Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, ShanghaiExpand
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Smad7 Is Required for the Development and Function of the Heart*
Transforming growth factor-β (TGF-β) family members, including TGF-βs, activins, and bone morphogenetic proteins, exert diverse biological activities in cell proliferation, differentiation,Expand
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[Foodborne disease outbreaks in China from 1992 to 2001 national foodborne disease surveillance system].
OBJECTIVE To study the foodborne disease outbreaks in the areas covered by National Foodborne Disease Surveillance System. METHODS Total 13 provinces were included in the surveillance system, andExpand
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Neogene uplift of the Tian Shan Mountains observed in the magnetic record of the Jingou River section (northwest China)
The Tian Shan Mountains constitute central Asia's longest and highest mountain range. Understanding their Cenozoic uplift history thus bears on mountain building processes in general, and on howExpand
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Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.
Metallothionein (MT) may provide protection against doxorubicin-induced heart damage. To test this hypothesis, a heart-specific promoter was used to drive the expression of human MT-IIa gene inExpand
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MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway*
  • J. Bao, D. Li, +8 authors C. Xu
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 8 May 2012
Background: MicroRNAs (miRNAs) are post-transcriptional regulators involved in the regulation of gene expression. Results: miR-449 and miR-34b/c function redundantly in male germ cells. Conclusion:Expand
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